microRNAs are small non-coding RNAs that regulate several genes post-transcriptionally by
complementarity pairing. Since discovery, they have been reported to be involved in a …

Neurons are among the most compartmentalized and interactive of all cell types. Like all
cells, neurons use proteins as the main sensors and effectors. The modification of the …

Axons extend for tremendously long distances from the neuronal soma and make use of
localized mRNA translation to rapidly respond to different extracellular stimuli and …

During nervous system development, neurons extend axons to reach their targets and form
functional circuits. The faulty assembly or disintegration of such circuits results in disorders …

Abstract N 6-methyladenosine (m6A) is a reversible modification in mRNA and has been
shown to regulate processing, translation and decay of mRNA. However, the roles of m6A …

The brain constantly adapts to changes in the environment, a capability that underlies
memory and behavior. Long-term adaptations require the remodeling of neural circuits that …

We report the construction of artificial cells that chemically communicate with mammalian
cells under physiological conditions. The artificial cells respond to the presence of a small …

Extracellular vesicles (EVs) have emerged as mediators of cellular communication, in part
via the delivery of associated microRNAs (miRNAs), small non-coding RNAs that regulate …

Nascent proteins can be positioned rapidly at precise subcellular locations by local protein
synthesis (LPS) to facilitate localized growth responses. Axon arbor architecture, a major …

Axonal protein synthesis and degradation are rapidly regulated by extrinsic signals during
neural wiring, but the full landscape of proteomic changes remains unknown due to …