Cardiac regeneration is a rapidly evolving and controversial field of research. The
identification some 12 years ago of progenitor cells that reside within the heart spurred …

▪ Abstract Communication between endothelial cells and cardiomyocytes regulates not only
early cardiac development but also adult cardiomyocyte function, including the contractile …

If and how the heart regenerates after an injury event is highly debated. c-kit-expressing
cardiac progenitor cells have been reported as the primary source for generation of new …

Stem cells have the potential to differentiate into cardiovascular cell lineages and to
stimulate tissue regeneration in a paracrine/autocrine manner; thus, they have been …

The goals of the study were:(1) to explore the communication between human mesenchymal
stem cells (MSC) and rat cardiac myocytes resulting in differentiation of the stem cells …

Cardiac progenitor cells are a potential source of cell therapy for heart failure. Although
recent studies have shown that transplantation of cardiac stem/progenitor cells improves …

Stem cell therapy has recently emerged as an innovative strategy over conventional
cardiovascular treatments to restore cardiac function in patients affected by ischemic heart …

Adult stem cells with multi or unipotent differentiation potential are present in almost all
tissues of adult organisms. The main function of these stem cells is to support normal repair …

This protocol describes the isolation of endogenous c-Kit (also known as CD117)-positive (c-
Kit+), CD45-negative (CD45−) cardiac stem cells (eCSCs) from whole adult mouse and rat …

Cardiac fibroblasts impact myocardial development and remodeling through intercellular
contact with cardiomyocytes, but less is known about noncontact, profibrotic signals whereby …