The coordinated action of the enzymes in the L-lysine biosynthetic pathway and how to inhibit it for antibiotic targets
Background Antimicrobial resistance is a global health issue that requires immediate
attention in terms of new antibiotics and new antibiotic targets. The l-lysine biosynthesis …
attention in terms of new antibiotics and new antibiotic targets. The l-lysine biosynthesis …
[图书][B] Enzymology of bacterial lysine biosynthesis
C Dogovski, SC Atkinson, SR Dommaraju, M Downton… - 2012 - scholar.archive.org
Lysine is an essential amino acid in the mammalian diet, but can be synthesised de novo in
bacteria, plants and some fungi (Dogovski et al., 2009; Hutton et al., 2007). In bacteria, the …
bacteria, plants and some fungi (Dogovski et al., 2009; Hutton et al., 2007). In bacteria, the …
Exploration of inhibitors for diaminopimelate aminotransferase
C Fan, MD Clay, MK Deyholos, JC Vederas - Bioorganic & Medicinal …, 2010 - Elsevier
Bacteria and higher plants make l-lysine from diaminopimelic acid (DAP). In mammals l-
lysine is an essential amino acid that must be acquired from the diet as the biosynthetic …
lysine is an essential amino acid that must be acquired from the diet as the biosynthetic …
Tetrahydrodipicolinate N-Succinyltransferase and Dihydrodipicolinate Synthase from Pseudomonas aeruginosa: Structure Analysis and Gene Deletion
R Schnell, W Oehlmann, T Sandalova, Y Braun… - PLoS …, 2012 - journals.plos.org
The diaminopimelic acid pathway of lysine biosynthesis has been suggested to provide
attractive targets for the development of novel antibacterial drugs. Here we report the …
attractive targets for the development of novel antibacterial drugs. Here we report the …
The three-dimensional structure of a mycobacterial DapD provides insights into DapD diversity and reveals unexpected particulars about the enzymatic mechanism
L Schuldt, S Weyand, G Kefala, MS Weiss - Journal of molecular biology, 2009 - Elsevier
The enzyme tetrahydrodipicolinate N-succinyltransferase (DapD) is part of the L-lysine
biosynthetic pathway. This pathway is crucial for the survival of the pathogen Mycobacterium …
biosynthetic pathway. This pathway is crucial for the survival of the pathogen Mycobacterium …
Reconstruction of diaminopimelic acid biosynthesis allows characterisation of Mycobacterium tuberculosis N-succinyl-L,L-diaminopimelic acid desuccinylase
With the increased incidence of tuberculosis (TB) caused by Mycobacterium tuberculosis
there is an urgent need for new and better anti-tubercular drugs. N-succinyl-L, L …
there is an urgent need for new and better anti-tubercular drugs. N-succinyl-L, L …
[PDF][PDF] Exploration of lysine pathway for developing newer anti-microbial analogs through enzyme inhibition approach
M Kale, MS Shaikh - Int. J. Pharm. Sci. Rev. Res, 2014 - researchgate.net
Recently, a renewed interest towards development of new antibacterial agents has been
created due to emergence of newer pathogenic bacterial strains showing high resistance to …
created due to emergence of newer pathogenic bacterial strains showing high resistance to …
[PDF][PDF] Drug discovery of newer analogs of anti-microbials through enzyme-inhibition: a review
M Kale, MS Shaikh - Int. J. Pharm. Pharm. Sci, 2014 - researchgate.net
There is a growing interest towards the development of new antibiotics from last decades
due to emergence of newer pathogenic bacterial strains with high resistance to powerful …
due to emergence of newer pathogenic bacterial strains with high resistance to powerful …
Characterization of left‐handed beta helix‐domains, and identification and functional annotation of proteins containing such domains
A Prabha, PV Balaji - Proteins: Structure, Function, and …, 2021 - Wiley Online Library
Abstract Only about 0.3% of the entries in UniProt database have manually curated
annotation. Annotation at the molecular level often relies on low‐throughput one‐protein‐at …
annotation. Annotation at the molecular level often relies on low‐throughput one‐protein‐at …
Computational modeling and evaluation of best potential drug targets through comparative modeling
JA Pradeepkiran, SB Sainath, PK Balne, M Bhaskar - Brucella Melitensis, 2021 - Elsevier
The present chapter provides details about the aspects related to homology modeling and
their structural validation of drug targets in Brucella militensis 16M through in silico analysis …
their structural validation of drug targets in Brucella militensis 16M through in silico analysis …