Applying lessons learned from nanomedicines to understand rare hypersensitivity reactions to mRNA-based SARS-CoV-2 vaccines

J Szebeni, G Storm, JY Ljubimova, M Castells… - Nature …, 2022 - nature.com
After over a billion of vaccinations with messenger RNA-lipid nanoparticle (mRNA-LNP)
based SARS-CoV-2 vaccines, anaphylaxis and other manifestations of hypersensitivity can …

Applications and limitations of dendrimers in biomedicine

AA Chis, C Dobrea, C Morgovan, AM Arseniu, LL Rus… - Molecules, 2020 - mdpi.com
Biomedicine represents one of the main study areas for dendrimers, which have proven to
be valuable both in diagnostics and therapy, due to their capacity for improving solubility …

[HTML][HTML] Emerging innate biological properties of nano-drug delivery systems: A focus on PAMAM dendrimers and their clinical potential

H Kheraldine, O Rachid, AM Habib… - Advanced drug delivery …, 2021 - Elsevier
Drug delivery systems or vectors are usually needed to improve the bioavailability and
effectiveness of a drug through improving its pharmacokinetics/pharmacodynamics at an …

Emerging concepts in dendrimer‐based nanomedicine: from design principles to clinical applications

RM Kannan, E Nance, S Kannan… - Journal of internal …, 2014 - Wiley Online Library
Dendrimers are discrete nanostructures/nanoparticles with 'onion skin‐like'branched layers.
Beginning with a core, these nanostructures grow in concentric layers to produce stepwise …

Environmental microplastic and nanoplastic: Exposure routes and effects on coagulation and the cardiovascular system

Z Lett, A Hall, S Skidmore, NJ Alves - Environmental Pollution, 2021 - Elsevier
Plastic pollution has been a growing concern in recent decades due to the proliferation and
ease of manufacturing of single use plastic products and inadequate waste and recycling …

[HTML][HTML] Current progress in gene delivery technology based on chemical methods and nano-carriers

L Jin, X Zeng, M Liu, Y Deng, N He - Theranostics, 2014 - ncbi.nlm.nih.gov
Gene transfer methods are promising in the field of gene therapy. Current methods for gene
transfer include three major groups: viral, physical and chemical methods. This review …

[HTML][HTML] PAMAM dendrimer-cell membrane interactions

LJ Fox, RM Richardson, WH Briscoe - Advances in colloid and interface …, 2018 - Elsevier
PAMAM dendrimers have been conjectured for a wide range of biomedical applications due
to their tuneable physicochemical properties. However, their application has been hindered …

Dendrimers in medicine: therapeutic concepts and pharmaceutical challenges

L Wu, M Ficker, JB Christensen… - Bioconjugate …, 2015 - ACS Publications
Dendrimers are three-dimensional macromolecular structures originating from a central core
molecule and surrounded by successive addition of branching layers (generation). These …

Collocalia birds inspired Janus-structured bandage with strong wet tissue adhesion for rapid hemostasis and wound healing

C Hui, Y Gao, BY Yan, LQ Ding, TC Sun, Z Liu… - Chemical Engineering …, 2023 - Elsevier
Powdered hemostatic agents, when encountered with high blood pressure bleeding, are
prone to being washed away by the blood flow, and there is a risk of entering the blood …

Understanding the correlation between in vitro and in vivo immunotoxicity tests for nanomedicines

MA Dobrovolskaia, SE McNeil - Journal of controlled release, 2013 - Elsevier
Preclinical characterization of novel nanotechnology-based formulations is often challenged
by physicochemical characteristics, sterility/sterilization issues, safety and efficacy. Such …