Intervertebral disc degeneration is a major cause of low back pain. Despite its long history
and large socio-economical impact in western societies, the initiation and progress of disc …

Purpose Low back pain (LBP) is the most disabling condition worldwide. Although LBP
relates to different spinal pathologies, vertebral bone marrow lesions visualized as Modic …

Excessive mechanical loading or acute trauma to intervertebral discs (IVDs) is thought to
contribute to degeneration and pain. However, the exact mechanisms by which mechanical …

The cartilaginous endplates (CEP) are key components of the intervertebral disc (IVD)
necessary for sustaining the nutrition of the disc while distributing mechanical loads and …

In recent decades the application of bioreactors has revolutionized the concept of culturing
tissues and organs that require mechanical loading. In intervertebral disc (IVD) research …

Low back pain is a leading cause of disability worldwide and the second most common
cause of physician visits. There are many causes of back pain, and among them, disc …

Intervertebral disc degeneration is implicated as a leading cause of low back pain.
Persistent, local inflammation within the disc nucleus pulposus (NP) and annulus fibrosus …

Study Design. In vitro experimental study. Objective. To establish an axial impact injury
model of intervertebral disc (IVD) and to investigate if a single impact injury without endplate …

Background Although deformation and fracture of the vertebral endplate have been
implicated in spinal conditions such as vertebral fracture and disc degeneration, few …

BACKGROUND Mounting evidence that oxidative stress contributes to the pathogenesis of
intervertebral disc (IVD) degeneration (IDD) suggests that therapies targeting oxidative …