Septic arthritis is a dangerous medical condition associated with significant morbidity and
mortality. However, the differential diagnosis can be broad with conditions that mimic this …

Hemophilia is a hematological disorder characterized by a partial or complete deficiency of
clotting factor VIII or IX. Its bleeding complications primarily affect the musculoskeletal …

Foundation Trust, Derby;‡ Haemophilia Centre, Royal Cornwall Hospitals NHS Trust, Truro;
§ Haemophilia Centre, Guys and St. Thomas' NHS Foundation Trust, London;¶ Katharine …

Aims Concizumab, a humanized monoclonal antibody against tissue factor pathway inhibitor
(TFPI), is being developed as a subcutaneously (sc) administered treatment for haemophilia …

Background: Prevention of hemarthrosis is the key factor in the adequate management of
people with hemophilia (PWH). If hemarthrosis occurs, early diagnosis of joint damage is …

Abstract Efanesoctocog alfa (rFVIIIFc-VWF-XTEN; BIVV001) is a new class of factor VIII
(FVIII) replacement that breaks the von Willebrand factor–imposed FVIII half-life ceiling. In a …

Introduction: The health benefits of prophylactic dosing regimens for clotting factor therapy in
patients with hemophilia include reduced joint damage and improved quality of life; as such …

Magnetic resonance imaging (MRI) and ultrasonography (US) are increasingly used in
haemophilia A (HA) to detect early joint changes. A total of 40 clinically asymptomatic joints …

Introduction People with haemophilia (PWH) experience end stage joint disease as a result
of repeated hemarthrosis, commonly leading to total knee arthroplasty (TKA). Aim The goal …

Hemophilia A is a worldwide disorder of coagulation system. It is a male disorder, yet
females with hemophilia are rarely seen in communities with high rate of consanguineous …