Old World Vipers—a review about snake venom proteomics of Viperinae and their variations

M Damm, BF Hempel, RD Süssmuth - Toxins, 2021 - mdpi.com
Fine-tuned by millions of years of evolution, snake venoms have frightened but also
fascinated humanity and nowadays they constitute potential resources for drug …

Snake venomics: fundamentals, recent updates, and a look to the next decade

CH Tan - Toxins, 2022 - mdpi.com
Venomic research, powered by techniques adapted from proteomics, transcriptomics, and
genomics, seeks to unravel the diversity and complexity of venom through which knowledge …

Small molecule drug discovery for neglected tropical snakebite

RH Clare, SR Hall, RN Patel, NR Casewell - Trends in pharmacological …, 2021 - cell.com
Snakebite envenoming is responsible for as many as 138 000 deaths annually, making it the
world's most lethal neglected tropical disease (NTD). There is an urgent need to improve …

Proteomic analysis reveals geographic variation in venom composition of Russell's Viper in the Indian subcontinent: Implications for clinical manifestations post …

B Kalita, SP Mackessy… - Expert review of proteomics, 2018 - Taylor & Francis
ABSTRACT Introduction: The Russell's Viper (RV)(Daboia russelii), a category I medically
important snake, is responsible for a significant level of morbidity and mortality in the Indian …

[HTML][HTML] Mutual enlightenment: A toolbox of concepts and methods for integrating evolutionary and clinical toxinology via snake venomics and the contextual stance

JJ Calvete, B Lomonte, AJ Saviola, F Bonilla, M Sasa… - Toxicon: X, 2021 - Elsevier
Snakebite envenoming is a neglected tropical disease that may claim over 100,000 human
lives annually worldwide. Snakebite occurs as the result of an interaction between a human …

A neurotoxic snake venom without phospholipase A2: Proteomics and cross-neutralization of the venom from Senegalese cobra, Naja senegalensis (Subgenus …

KY Wong, KY Tan, NH Tan, CH Tan - Toxins, 2021 - mdpi.com
The Senegalese cobra, Naja senegalensis, is a non-spitting cobra species newly erected
from the Naja haje complex. Naja senegalensis causes neurotoxic envenomation in …

Quantitative proteomics of Naja annulifera (sub-Saharan snouted cobra) venom and neutralization activities of two antivenoms in Africa

KY Tan, KY Wong, NH Tan, CH Tan - International journal of biological …, 2020 - Elsevier
Envenomation by Naja annulifera (snouted cobra), a non-spitting African cobra, can result in
local tissue damage and fatal paralysis but a species-specific antivenom treatment is …

Antivenom preclinical efficacy testing against Asian snakes and their availability in Asia: A systematic review

S Soopairin, C Patikorn, S Taychakhoonavudh - PloS one, 2023 - journals.plos.org
Background Cross-neutralizing strategy has been applied to improve access to antivenoms,
a key to reducing mortality and disability of snakebite envenoming. However, preclinical …

Venom Proteome of Spine-Bellied Sea Snake (Hydrophis curtus) from Penang, Malaysia: Toxicity Correlation, Immunoprofiling and Cross-Neutralization by Sea …

CH Tan, KY Tan, TS Ng, SM Sim, NH Tan - Toxins, 2018 - mdpi.com
The venom proteome of Hydrophis curtus (synonym: Lapemis hardwickii) from Penang,
Malaysia was investigated with nano-electrospray ionization-liquid chromatography tandem …

Proteomic insights into short neurotoxin-driven, highly neurotoxic venom of Philippine cobra (Naja philippinensis) and toxicity correlation of cobra envenomation in …

CH Tan, KY Wong, HP Chong, NH Tan, KY Tan - Journal of proteomics, 2019 - Elsevier
Abstract The Philippine cobra, Naja philippinensis, is a WHO Category 1 venomous snake of
medical importance responsible for fatal envenomation in the northern Philippines. To …