Cancer therapy in the necroptosis era

Z Su, Z Yang, L Xie, JP DeWitt, Y Chen - Cell Death & Differentiation, 2016 - nature.com
Necroptosis is a caspase-independent form of regulated cell death executed by the receptor-
interacting protein kinase 1 (RIP1), RIP3, and mixed lineage kinase domain-like protein …

MicroRNAs in cancer cell death pathways: Apoptosis and necroptosis

S Shirjang, B Mansoori, S Asghari, PHG Duijf… - Free Radical Biology …, 2019 - Elsevier
To protect tissues and the organism from disease, potentially harmful cells are removed
through programmed cell death processes, including apoptosis and necroptosis. These …

Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer

C Zhang, N Liu - Frontiers in immunology, 2022 - frontiersin.org
Ovarian cancer (OC) is one of the most common malignancies that causes death in women
and is a heterogeneous disease with complex molecular and genetic changes. Because of …

Suspension polymerization technique: parameters affecting polymer properties and application in oxidation reactions

V Chaudhary, S Sharma - Journal of Polymer Research, 2019 - Springer
Various heterogeneous polymerization techniques such as suspension, emulsion,
dispersion, precipitation and seeded are employed for the synthesis of a wide variety of …

Targeting necroptosis as an alternative strategy in tumor treatment: From drugs to nanoparticles

X Zang, J Song, Y Li, Y Han - Journal of Controlled Release, 2022 - Elsevier
Over last decades, most antitumor therapeutic strategies have focused on apoptosis,
however, apoptosis resistance and immunological silence usually led to treatment failure. In …

The role of necroptosis in cancer: A double-edged sword?

X Qin, D Ma, Y Tan, H Wang, Z Cai - … et Biophysica Acta (BBA)-Reviews on …, 2019 - Elsevier
Necroptosis is a programmed, caspase-independent cell death that is morphologically
similar to necrosis. Unlike apoptosis, necroptosis evokes inflammatory responses by …

HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death

AV Jacobsen, KN Lowes, MC Tanzer, IS Lucet… - Cell death & …, 2016 - nature.com
Necroptosis is a caspase-independent form of regulated cell death that has been implicated
in the development of a range of inflammatory, autoimmune and neurodegenerative …

Platinum drugs and taxanes: can we overcome resistance?

EV Sazonova, GS Kopeina, EN Imyanitov… - Cell death …, 2021 - nature.com
Cancer therapy is aimed at the elimination of tumor cells and acts via the cessation of cell
proliferation and induction of cell death. Many research publications discussing the …

[HTML][HTML] Non-apoptotic cell death in ovarian cancer: Treatment, resistance and prognosis

J Chen, Z Wei, K Fu, Y Duan, M Zhang, K Li… - Biomedicine & …, 2022 - Elsevier
Ovarian cancer is mostly diagnosed at an advanced stage due to the absence of effective
screening methods and specific symptoms. Repeated chemotherapy resistance and …

Redox biology of regulated cell death in cancer: A focus on necroptosis and ferroptosis

C Florean, S Song, M Dicato, M Diederich - Free Radical Biology and …, 2019 - Elsevier
Redox changes and generation of reactive oxygen species (ROS) are part of normal cell
metabolism. While low ROS levels are implicated in cellular signaling pathways necessary …