Cathepsin B in programmed cell death machinery: mechanisms of execution and regulatory pathways
Z Xie, M Zhao, C Yan, W Kong, F Lan… - Cell Death & …, 2023 - nature.com
Cathepsin B (CatB), a cysteine protease, is primarily localized within subcellular endosomal
and lysosomal compartments. It is involved in the turnover of intracellular and extracellular …
and lysosomal compartments. It is involved in the turnover of intracellular and extracellular …
Bromodomains in human-immunodeficiency virus-associated neurocognitive disorders: a model of ferroptosis-induced neurodegeneration
A Sfera, KG Thomas, CV Andronescu, N Jafri… - Frontiers in …, 2022 - frontiersin.org
Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND)
comprise a group of illnesses marked by memory and behavioral dysfunction that can occur …
comprise a group of illnesses marked by memory and behavioral dysfunction that can occur …
Quantitative Proteomics Reveal That CB2R Agonist JWH-133 Downregulates NF-κB Activation, Oxidative Stress, and Lysosomal Exocytosis from HIV-Infected …
LJ Rosario-Rodríguez, YM Cantres-Rosario… - International Journal of …, 2024 - mdpi.com
HIV-associated neurocognitive disorders (HAND) affect 15–55% of HIV-positive patients and
effective therapies are unavailable. HIV-infected monocyte-derived macrophages (MDM) …
effective therapies are unavailable. HIV-infected monocyte-derived macrophages (MDM) …
[HTML][HTML] Comparative transcriptomic analysis reveals the molecular changes of acute pancreatitis in experimental models
P Zheng, XY Li, XY Yang, H Wang, L Ding… - World Journal of …, 2024 - ncbi.nlm.nih.gov
BACKGROUND Acute pancreatitis (AP) encompasses a spectrum of pancreatic
inflammatory conditions, ranging from mild inflammation to severe pancreatic necrosis and …
inflammatory conditions, ranging from mild inflammation to severe pancreatic necrosis and …
[HTML][HTML] Analysis of Sigma-1 Receptor Antagonist BD1047 Effect on Upregulating Proteins in HIV-1-Infected Macrophages Exposed to Cocaine Using Quantitative …
O Vélez-López, K Carrasquillo-Carrión… - Biomedicines, 2024 - mdpi.com
HIV-1 infects monocyte-derived macrophages (MDM) that migrate into the brain and secrete
virus and neurotoxic molecules, including cathepsin B (CATB), causing cognitive …
virus and neurotoxic molecules, including cathepsin B (CATB), causing cognitive …
Inhibition of cathepsin B blocks amyloidogenesis in the mouse models of neurological lysosomal diseases mucopolysaccharidosis type IIIC and sialidosis
GM Viana, X Pan, S Fan, TM Xu, A Wyatt… - bioRxiv, 2025 - biorxiv.org
Neuronal accumulation of amyloid aggregates is a hallmark of brain pathology in
neurological lysosomal storage diseases (LSDs) including mucopolysaccharidoses (MPS) …
neurological lysosomal storage diseases (LSDs) including mucopolysaccharidoses (MPS) …
Selective neutral ph inhibitor of cathepsin b
A O'donoghue, V Hook, M Yoon… - US Patent App. 18 …, 2024 - Google Patents
Pharmaceutical compositions comprising a peptidic inhibitor of cathepsin B, such as Z-Arg-
Lys-AOMK (ZRK-AOMK). Methods for inhibiting neutral pH cathepsin B activity, comprising …
Lys-AOMK (ZRK-AOMK). Methods for inhibiting neutral pH cathepsin B activity, comprising …