During neurodegenerative disease, the multifunctional RNA-binding protein TDP-43
undergoes a vast array of post-translational modifications, including phosphorylation …

The discovery of intrinsically disordered proteins (IDP)(ie, biologically active proteins that do
not possess stable secondary and/or tertiary structures) came as an unexpected surprise, as …

The 5′ cap structures of higher eukaryote mRNAs have ribose 2′-O-methylation.
Likewise, many viruses that replicate in the cytoplasm of eukaryotes have evolved 2′-O …

Uterine leiomyomas, or fibroids, are benign tumors that affect millions of women worldwide
and that can cause considerable morbidity. To study the genetic basis of this tumor type, we …

Pseudomonas aeruginosa, the principal pathogen of cystic fibrosis patients, forms antibiotic‐
resistant biofilms promoting chronic colonization of the airways. The extracellular (EPS) …

X-ray crystallography is an established method for studying the structure of proteins and
other macromolecules. As the importance of proteins grows, researchers in many fields have …

Schistosomiasis is a neglected tropical disease caused by blood flukes (genus
Schistosoma; schistosomes) and affecting 200 million people worldwide. No vaccines are …

Chronic obstructive pulmonary disease and pulmonary fibrosis have been hypothesized to
represent premature aging phenotypes. At times, they cluster in families, but the genetic …

Background Autoimmune and autoinflammatory diseases involve interactions between
genetic risk factors and environmental triggers. We searched for a gene on chromosome …

The chromogranins (chromogranin A and chromogranin B), secretogranins (secretogranin II
and secretogranin III), and additional related proteins (7B2, NESP55, proSAAS, and VGF) …