Octamer-binding transcription factor 4 (Oct4), a homeodomain transcription factor, is well
established as a master factor controlling the self-renewal and pluripotency of pluripotent …

A controlled regulation of mitochondrial mass through either the production (biogenesis) or
the degradation (mitochondrial quality control) of the organelle represents a crucial step for …

Functional interpretation of candidate gene lists is an essential task in modern biomedical
research. Here, we present the 2011 update of g: Profiler (http://biit. cs. ut. ee/gprofiler/), a …

Embryonic stem cells (ESCs) maintain high genomic plasticity, which is essential for their
capacity to enter diverse differentiation pathways. Posttranscriptional modifications of …

Signaling via the Akt serine/threonine protein kinase plays critical roles in the self-renewal of
embryonic stem cells and their malignant counterpart, embryonal carcinoma cells (ECCs) …

POU5F1 plays an important role in maintaining the cancer stem cell (CSC)-like properties of
gastric cancer (GC) cells. The impact of POU5F1 on the proliferation and metastasis of GC …

Cancer stem-like cells (CSLC) are crucial in tumor initiation and progression; however, the
underlying mechanism for the self-renewal of cancer cells remains undefined. In the study …

Background Octamer-binding transcription factor 4 (OCT4) is a key stem cell transcription
factor involved in the development of various cancers. The role of OCT4 in ovarian cancer …

Background OCT4 and BIRC5 are preferentially expressed in human cancer cells and
mediate cancer cell survival and tumor maintenance. However, the molecular mechanism …

The transforming growth factor-β (TGFβ) family factors induce pleiotropic effects and are
involved in the regulation of most normal and pathological cellular processes. The activity of …