In this exploratory case–control study, we investigated basal cortisol regulation in 5–16-year-
old children, 3–6 months following PICU (paediatric intensive care) admission. This was …

Adrenal insufficiency (AI) is a life-threatening disorder. Defects at any level of the
hypothalamic-pituitary-adrenal axis can impair adrenal function. It is difficult to make a …

Background Critically ill children suffer from impaired physical/neurocognitive development
2 years later. Glucocorticoid treatment alters DNA methylation within the hypothalamus …

Purpose Increased systemic cortisol availability during adult critical illness is determined by
reduced binding-proteins and suppressed breakdown rather than elevated ACTH …

Elevated cortisol level is an component of the stress response. However, some patients
have low cortisol levels; a condition termed: critical illness-related corticosteroid insufficiency …

Background Critically ill patients, including those with sepsis, have increased cortisol levels
due to activation of the hypothalamic-pituitary-adrenal (HPA) axis or critical illness-related …

Background Relative adrenal insufficiency (RAI) is the inadequate production of cortisol due
to dysfunction of the hypothalamic–pituitary–adrenal (HPA) axis during a severe illness. We …

Öz Address for Correspondence: Fatma Neslihan Çuhacı MD, Atatürk Training and
Research Hospital, Clinic of Endocrinology and Metabolism, Ankara, Turkey Phone:+ 90 …

Activation of the hypothalamic-pituitary-adrenal axis with the production of cortisol is a
fundamental component of the stress response and is essential for survival of the host in …

Background: Critical illness is the medical condition in which a patient requires immediate
intensive medical support of vital organ functions in order to survive. Independent of the …