Polyunsaturated fatty acids (PUFAs) are lipid derivatives of omega-3 (docosahexaenoic
acid, DHA, and eicosapentaenoic acid, EPA) or of omega-6 (arachidonic acid, ARA) …

Transient receptor potential (TRP) channels are a large, eukaryotic ion channel superfamily
that control diverse physiological functions, and therefore are attractive drug targets,,,–. More …

The transient receptor potential vanilloid 4 (TRPV4) is a highly Ca 2+-permeable non-
selective cation channel in TRPV family. Accumulating evidence hints that TRPV4 play a …

Upon its release from injured cells, such as infected, transformed, inflamed, or necrotic cells,
extracellular adenosine-5ʹ-triphosphate (ATP) acts as a danger signal that recruits …

Transient receptor potential vanilloid (TRPV) channels are activated by ligands and heat
and are involved in various physiological processes. In contrast to the architecturally related …

ABSTRACT Nociceptive Transient Receptor Potential channels such as TRPV1 are targets
for treating pain. Both antagonism and agonism of TRP channels can promote analgesia …

Cannabinoid compounds are potential analgesics. Users of medicinal Cannabis report
efficacy for pain control, clinical studies show that cannabis can be effective and opioid …

Over the last decades, a great array of molecular mediators have been identified as potential
targets for the treatment of chronic pain. Among these mediators, transient receptor potential …

Absorption of ammonia from the gastrointestinal tract results in problems that range from
hepatic encephalopathy in humans to poor nitrogen efficiency of cattle with consequences …

Transient receptor potential (TRP) channels are broadly implicated in the developmental
programs of most tissues. Amongst these tissues, skeletal muscle and adipose are …