Advances in the In vitro and In vivo pharmacology of Alpha4beta2 nicotinic receptor positive allosteric modulators
Receptors containing α4 and β2 subunits are a major neuronal nicotinic acetylcholine
receptor (nAChR) subtype in the brain. This receptor plays a critical role in nicotine …
receptor (nAChR) subtype in the brain. This receptor plays a critical role in nicotine …
More than smoke and patches: the quest for pharmacotherapies to treat tobacco use disorder
MJ Moerke, LR McMahon, JL Wilkerson… - Pharmacological …, 2020 - Elsevier
Tobacco use is a persistent public health issue. It kills up to half its users and is the cause of
nearly 90% of all lung cancers. The main psychoactive component of tobacco is nicotine …
nearly 90% of all lung cancers. The main psychoactive component of tobacco is nicotine …
Effects of the specific α4β2 nAChR antagonist, 2-fluoro-3-(4-nitrophenyl) deschloroepibatidine, on nicotine reward-related behaviors in rats and mice
KM Tobey, DM Walentiny, JL Wiley, FI Carroll… - …, 2012 - Springer
Rationale Alleviating addiction to tobacco products could prevent millions of deaths.
Investigating novel compounds selectively targeting α4β2 nAChRs hypothesized to have a …
Investigating novel compounds selectively targeting α4β2 nAChRs hypothesized to have a …