ABSTRACT A common focus among molecular and cellular biologists is the identification of
proteins that interact with each other. Yeast two‐hybrid, cDNA expression library screening …

Crk family adaptors are widely expressed and mediate the timely formation of signal
transduction protein complexes upon a variety of extracellular stimuli, including various …

Background Microcell-mediated transfer of chromosome 6 into human C8161 and MelJuSo
melanoma cells suppresses their ability to metastasize by at least 95% without affecting their …

The c-Abl tyrosine kinase is inhibited by mechanisms that are poorly understood. Disruption
of these mechanisms in the Bcr-Abl oncoprotein leads to several forms of human leukemia …

In the past few years genetic, biochemical, and cytolocalization data have implicated
members of the myosin superfamily of actin-based molecular motors in a variety of cellular …

▪ Abstract A characteristic feature of cellular signal transduction pathways in eukaryotes is
the separation of catalysis from target recognition. Several modular domains that recognize …

Carcinoma cells selected for their ability to migrate in vitro showed enhanced invasive
properties in vivo. Associated with this induction of migration was the anchorage-dependent …

THE product of the c-abl gene is a non-receptor tyrosine kinase that is localized to the
nucleus and cytoplasm. The precise function of c-Abl is unknown. Here we show that …

Cancer cells require sustained oncogenic signaling in order to maintain their malignant
properties. It is, however, unclear whether they possess other dependencies that can be …

Synapse-associated proteins (SAPs) are constituents of the pre-and postsynaptic
submembraneous cytomatrix. Here, we present SAP102, a novel 102 kDa SAP detected in …