Colorectal cancer (CRC) is the third most common cancer and has a high metastasis and
reoccurrence rate. Long noncoding RNAs (lncRNAs) play an important role in CRC growth …

Solid tumors often grow in a micro-environment characterized by< 2% O 2 tension. This
condition, together with the aberrant activation of specific oncogenic patwhays, increases …

Cancer constitutes a grave problem nowadays in view of the fact that it has become one of
the main causes of death worldwide. Poor clinical prognosis is presumably due to cancer …

Simple Summary The complex signaling networks that different cancers utilize for cell
survival remain poorly understood. A major problem is the complexity of the tumor …

Collagen is the main component of the extracellular matrix. Hydroxylation of proline residues
on collagen, catalyzed by collagen prolyl 4-hydroxylase (C-P4H), is essential for the stability …

Cell migration-inducing hyaluronidase 1 (CEMIP), a Wnt-related protein and also known as
KIAA1199, is implicated in the process of metastatic colonization in a variety of malignant …

Brain metastases represent a substantial amount of morbidity and mortality in breast cancer
(BC). Metastatic breast tumor cells committed to brain metastases are unique because they …

KIAA1199, also known as CEMIP or HYBID, is an important member of the Human
Unidentified Gene-Encoded (HUGE) database. Accumulated evidence has revealed that …

Background The ring-shaped cohesin complex is an important factor for the formation of
chromatin loops and topologically associating domains (TADs) by loop extrusion. However …

Background Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer
with a high mortality rate due to a lack of therapeutic targets. Many TNBC cells are reliant on …