An increased expression of members of the matrix metalloproteinase (MMP) family of
enzymes is seen in almost every human tissue in which inflammation is present. Through …

The role of the host extracellular matrix (ECM) in infection tends to be neglected. However,
the complex interactions between invading pathogens, host tissues and immune cells occur …

Classically, the extracellular matrix (ECM) was viewed as a supporting structure for
stabilizing the location of cells in tissues and for preserving the architecture of tissues. This …

Chronic neutrophilic inflammation is a manifestation of a variety of lung diseases including
cystic fibrosis (CF). There is increasing evidence that fragments of extracellular matrix …

CD4+ T cell responses are critical for the pathogenesis of Helicobacter pylori infection. The
present study evaluated the role of the Th17 subset in H. pylori infection. H. pylori infection …

Matrix metalloproteinases (MMPs) play essential physiologic roles in numerous processes
ranging from development to wound repair. Unfortunately, given the broad substrate …

The mammalian immune system is optimized to cope effectively with the constant threat of
pathogens. However, when the immune system overreacts, sepsis, severe sepsis, or septic …

West Nile virus (WNV) is the most-common cause of mosquito-borne encephalitis in the
United States. Invasion of the brain by WNV is influenced by viral and host factors, and the …

Francisella tularensis has been recognized as the causative agent of tularaemia for almost a
century. Since its discovery in 1911, it has been shown to infect a wide range of hosts …

Acute lung injury (ALI) is a clinical disease marked by respiratory failure due to disruption of
the epithelial and endothelial barrier, flooding of the alveolar compartment with protein-rich …