The scope and purpose of this work is 2-fold: to synthesize the available evidence and to
translate it into recommendations. This document provides recommendations only when …

Cerebral edema (CE) and resultant intracranial hypertension are associated with
unfavorable prognosis in traumatic brain injury (TBI). CE is a leading cause of in-hospital …

Sixty years have passed since neurosurgeon Nils Lundberg presented his thesis about
intracranial pressure (ICP) monitoring, which represents a milestone for its clinical …

Introduction Individualising therapy is an important challenge for intensive care of patients
with severe traumatic brain injury (TBI). Targeting a cerebral perfusion pressure (CPP) …

Intracranial pressure (ICP) measurements are essential in evaluation and treatment of
neurological disorders such as subarachnoid and intracerebral hemorrhage, ischemic …

Elevated intracranial pressure (ICP) is an important cause of secondary brain injury, and a
measurement of ICP is often of crucial value in neurosurgical and neurological patients. The …

Cortical spreading depolarization causes a breakdown of electrochemical gradients
following acute brain injury, and also elicits dynamic changes in regional cerebral blood flow …

Subarachnoid hemorrhage (SAH) is a devastating stroke subtype with a high rate of
mortality and morbidity. The poor clinical outcome can be attributed to the biphasic course of …

Transcranial Doppler (TCD) ultrasonography is a noninvasive bedside monitoring technique
that can evaluate cerebral blood flow hemodynamics in the intracranial arterial vasculature …

Object In severe traumatic brain injury, a universal target for cerebral perfusion pressure
(CPP) has been abandoned. Attempts to identify a dynamic CPP target based on the …