Using zebrafish to model autism spectrum disorder: a comparison of ASD risk genes between zebrafish and their mammalian counterparts

V Rea, TJ Van Raay - Frontiers in molecular neuroscience, 2020 - frontiersin.org
Autism spectrum disorders (ASDs) are a highly variable and complex set of neurological
disorders that alter neurodevelopment and cognitive function, which usually presents with …

Gene editing in monogenic autism spectrum disorder: animal models and gene therapies

N Wang, L Lv, X Huang, M Shi, Y Dai, Y Wei… - Frontiers in Molecular …, 2022 - frontiersin.org
Autism spectrum disorder (ASD) is a lifelong neurodevelopmental disease, and its diagnosis
is dependent on behavioral manifestation, such as impaired reciprocal social interactions …

Early environmental enrichment for autism spectrum disorder Fmr1 mice models has positive behavioral and molecular effects

Y Chen, S Zhang, C Yue, P Xiang, J Li, Z Wei, L Xu… - Experimental …, 2022 - Elsevier
Autism spectrum disorder is a complex neurodevelopmental condition with genetic and
phenotypic heterogeneity characterized by hallmark impairments in social functioning and …

Early 7, 8-dihydroxyflavone administration ameliorates synaptic and behavioral deficits in the young FXS animal model by acting on BDNF-TrkB pathway

Y Chen, S Zhang, W Tan, Q Zhu, C Yue, P Xiang… - Molecular …, 2023 - Springer
Fragile X syndrome (FXS) is the leading inherited form of intellectual disability and the most
common cause of autism spectrum disorders. FXS patients exhibit severe syndromic …

Zebrafish models of autosomal dominant ataxias

A Quelle-Regaldie, D Sobrido-Cameán… - Cells, 2021 - mdpi.com
Hereditary dominant ataxias are a heterogeneous group of neurodegenerative conditions
causing cerebellar dysfunction and characterized by progressive motor incoordination …

Loss of FMRP affects ovarian development and behaviour through multiple pathways in a zebrafish model of fragile X syndrome

R Rani, NS Sri, R Medishetti, K Chatti… - Human Molecular …, 2024 - academic.oup.com
Fragile X syndrome (FXS) is an inherited neurodevelopmental disorder and the leading
genetic cause of autism spectrum disorders. FXS is caused by loss of function mutations in …

Neurogenic Effects of Inorganic Arsenic and Cdk5 Knockdown in Zebrafish Embryos: A Perspective on Modeling Autism

Q Gu, J Kanungo - International Journal of Molecular Sciences, 2024 - mdpi.com
The exact mechanisms of the development of autism, a multifactorial neurological disorder,
are not clear. The pathophysiology of autism is complex, and investigations at the cellular …

Neuroprotective potential of solanesol against tramadol induced zebrafish model of Parkinson's disease: insights from neurobehavioral, molecular, and …

MR Alam, V Dobhal, S Singh - Drug and Chemical Toxicology, 2024 - Taylor & Francis
Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by the
loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and subsequent …

Advances in animal models and cutting-edge research in alternatives: Proceedings of the second international conference on 3Rs research and progress, hyderabad …

A Sonawane, B Vadloori, S Poosala… - Alternatives to …, 2022 - journals.sagepub.com
The fact that animal models fail to replicate human disease faithfully is now being widely
accepted by researchers across the globe. As a result, they are exploring the use of …

Novel sequential DNA circuits using DNAzymes

Y Sun, Y Xiao, Z Gong, X Zhong… - IEEE Transactions on …, 2022 - ieeexplore.ieee.org
DNA circuits, consisting of DNAzyme library logic gates that relay DNA strand displacement
reactions, have been proven to harness massive parallel computing abilities in a biologically …