Genetics of glutamate and its receptors in autism spectrum disorder
Autism spectrum disorder (ASD) is a neurodevelopmental impairment characterized by
deficits in social interaction skills, impaired communication, and repetitive and restricted …
deficits in social interaction skills, impaired communication, and repetitive and restricted …
Advancing the understanding of autism disease mechanisms through genetics
Progress in understanding the genetic etiology of autism spectrum disorders (ASD) has
fueled remarkable advances in our understanding of its potential neurobiological …
fueled remarkable advances in our understanding of its potential neurobiological …
Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma
I Tirosh, AS Venteicher, C Hebert, LE Escalante… - Nature, 2016 - nature.com
Although human tumours are shaped by the genetic evolution of cancer cells, evidence also
suggests that they display hierarchies related to developmental pathways and epigenetic …
suggests that they display hierarchies related to developmental pathways and epigenetic …
[HTML][HTML] Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism
Genetic studies have identified dozens of autism spectrum disorder (ASD) susceptibility
genes, raising two critical questions:(1) do these genetic loci converge on specific biological …
genes, raising two critical questions:(1) do these genetic loci converge on specific biological …
Bridging animal and human models of exercise-induced brain plasticity
Significant progress has been made in understanding the neurobiological mechanisms
through which exercise protects and restores the brain. In this feature review, we integrate …
through which exercise protects and restores the brain. In this feature review, we integrate …
[HTML][HTML] The BAF complex interacts with Pax6 in adult neural progenitors to establish a neurogenic cross-regulatory transcriptional network
J Ninkovic, A Steiner-Mezzadri, M Jawerka, U Akinci… - Cell stem cell, 2013 - cell.com
Numerous transcriptional regulators of neurogenesis have been identified in the developing
and adult brain, but how neurogenic fate is programmed at the epigenetic level remains …
and adult brain, but how neurogenic fate is programmed at the epigenetic level remains …
MicroRNAs induce a permissive chromatin environment that enables neuronal subtype-specific reprogramming of adult human fibroblasts
Directed reprogramming of human fibroblasts into fully differentiated neurons requires
massive changes in epigenetic and transcriptional states. Induction of a chromatin …
massive changes in epigenetic and transcriptional states. Induction of a chromatin …
Proliferation and differentiation deficits are a major convergence point for neurodevelopmental disorders
C Ernst - Trends in neurosciences, 2016 - cell.com
Several lines of evidence suggest that proliferation and differentiation in neural stem cells
(NSCs) are a major convergence point of neurodevelopmental disorders (NDDs). Most …
(NSCs) are a major convergence point of neurodevelopmental disorders (NDDs). Most …
Ezh2 regulates adult hippocampal neurogenesis and memory
J Zhang, F Ji, Y Liu, X Lei, H Li, G Ji… - Journal of …, 2014 - Soc Neuroscience
Adult neurogenesis is thought to be crucial for preserving cognitive functions, which is tightly
controlled by various epigenetic regulators. As the methyltransferase of histone H3K27, the …
controlled by various epigenetic regulators. As the methyltransferase of histone H3K27, the …
Small molecules modulate chromatin accessibility to promote NEUROG2-mediated fibroblast-to-neuron reprogramming
Pro-neural transcription factors and small molecules can induce the reprogramming of
fibroblasts into functional neurons; however, the immediate-early molecular events that …
fibroblasts into functional neurons; however, the immediate-early molecular events that …