Schiff bases are versatile organic compounds which are widely used and synthesized by
condensation reaction of different amino compound with aldehydes or ketones known as …

Accurate DNA replication and repair is essential for proper development, growth and tumor-
free survival in all multicellular organisms. A key requirement for the maintenance of …

Metal-based antitumor drugs play a relevant role in antiblastic chemotherapy. Cisplatin is
regarded as one of the most effective drugs, even if severe toxicities and drug resistance …

The chemical and biological effects of thiosemicarbazones have received considerable
interest from medicinal chemists for many years. This is attributed to, first, their wide …

Previous studies from our laboratories have shown that (a) Triapine™ is a potent inhibitor of
ribonucleotide reductase activity and (b) hydroxyurea-resistant L1210 leukemia cells are …

Metals and metal compounds have been used in medicine for several thousands of years. In
this review we summarized the anti-cancer activities of the ten most active metals: arsenic …

Currently, cancer and its progression to metastasis result in a large number of deaths. The
lack of new drugs, appropriate clinical trials for metastasis preventive drugs and incomplete …

phenyl‐3‐methyl‐4‐benzoyl‐5‐pyrazolone 4‐ethyl‐thiosemicarbazone (HL) and its copper
(II), vanadium (V) and nickel (II) complexes:[Cu (L)(Cl)]· C2H5OH·(1),[Cu (L) 2]· H2O (2),[Cu …

Significance: Under normal circumstances, cellular iron levels are tightly regulated due to
the potential toxic effects of this metal ion. There is evidence that tumors possess altered iron …

Newer and more potent therapies are urgently needed to effectively treat advanced cancers
that have developed resistance and metastasized. One such strategy is to target cancer cell …