Profiling the immune response to periprosthetic joint infection and non-infectious arthroplasty failure

CR Fisher, R Patel - Antibiotics, 2023 - mdpi.com
Arthroplasty failure is a major complication of joint replacement surgery. It can be caused by
periprosthetic joint infection (PJI) or non-infectious etiologies, and often requires surgical …

Translational medicine: challenges and new orthopaedic vision (Mediouni-Model)

M Mediouni, R Madiouni, M Gardner… - Current orthopaedic …, 2020 - journals.lww.com
Abstract In North America and three European countries translational medicine (TM) funding
has taken center stage as the National Institutes of Health (NIH), for example, has come to …

Combined measurement of D-dimer and C-reactive protein levels: highly accurate for diagnosing chronic periprosthetic joint infection

L Qin, F Li, X Gong, J Wang, W Huang, N Hu - The Journal of arthroplasty, 2020 - Elsevier
Background Diagnosis of chronic periprosthetic joint infection (PJI) can be challenging and
elusive in the absence of a gold standard. D-dimer plays an important role in inflammation …

Globulin, the albumin-to-globulin ratio, and fibrinogen perform well in the diagnosis of Periprosthetic joint infection

H Wang, H Zhou, R Jiang, Z Qian, F Wang… - BMC musculoskeletal …, 2021 - Springer
Background Although periprosthetic joint infection (PJI) is a severe complication of total joint
arthroplasty (TJA), the diagnosis of PJI remains challenging. Albumin (ALB), globulin (GLB) …

Current relevance of biomarkers in diagnosis of periprosthetic joint infection: an update

S Tripathi, S Tarabichi, J Parvizi, A Rajgopal - Arthroplasty, 2023 - Springer
With a significant rise in the number of arthroplasty procedures performed worldwide, the
increasing revision burden posed by periprosthetic joint infection (PJI) is a matter of growing …

Synovial fluid pH sensor for early detection of prosthetic hip infections

UN Wijayaratna, SD Kiridena, JD Adams… - Advanced functional …, 2021 - Wiley Online Library
An implantable sensor developed to measure synovial fluid pH for noninvasive early
detection and monitoring of hip infections using standard‐of‐care plain radiography is …

Risk factors, diagnosis and management of prosthetic joint infection after total hip arthroplasty

SS Ahmed, F Begum, B Kayani… - Expert review of medical …, 2019 - Taylor & Francis
Introduction: Although a relatively rare complication, the incidence and prevalence of
prosthetic joint infection (PJI) is certainly rising. This is mainly due to the number of …

Fibrinogen–a practical and cost efficient biomarker for detecting periprosthetic joint infection

SM Klim, F Amerstorfer, G Gruber, GA Bernhardt… - Scientific reports, 2018 - nature.com
The early and accurate diagnosis of periprosthetic joint infection (PJI) can be challenging.
Fibrinogen plays an important role in mediating inflammation of bacterial infections and …

Acidity Is an Excellent Marker of Infection in Hip and Knee Arthroplasty

T Judl, S Popelka, E Tomšík, M Hrubý, M Daniel… - Journal of Clinical …, 2024 - mdpi.com
Background: The diagnosis of joint replacement infection is a difficult clinical challenge that
often occurs when the implant cannot be salvaged. We hypothesize that the pH value of …

Combined serum and synovial C-reactive protein tests: a valuable adjunct to the diagnosis of chronic prosthetic joint infection

H Wang, L Qin, J Wang, N Hu, W Huang - BMC Musculoskeletal Disorders, 2021 - Springer
Background Diagnosis of periprosthetic joint infection (PJI), especially chronic PJI, is very
confusing and challenging. The value of C-reactive protein (CRP) in infectious diseases has …