The interplay between chromatin, transcription factors and genes generates complex
regulatory circuits that can be represented as gene regulatory networks (GRNs). The study …

Eukaryotic gene regulation is a combinatorial, dynamic, and quantitative process that plays
a vital role in development and disease and can be modeled at a systems level in gene …

Cell type-specific gene expression patterns are outputs of transcriptional gene regulatory
networks (GRNs) that connect transcription factors and signaling proteins to target genes …

The persistent cereal endosperm constitutes the majority of the grain volume. Dissecting the
gene regulatory network underlying cereal endosperm development will facilitate yield and …

Gene regulatory networks (GRNs) represent the interactions between transcription factors
(TF) and their target genes. Plant GRNs control transcriptional programs involved in growth …

The evolutionary dynamics of cancer, characterized by its profound heterogeneity, demand
sophisticated tools for a holistic understanding. This review delves into tumor phylogenetics …

Single-cell RNA sequencing (scRNA-seq) is a key technology for investigating cell
development and analysing cell diversity across various diseases. However, the high …

Motivation The molecular identity of a cell results from a complex interplay between
heterogeneous molecular layers. Recent advances in single-cell sequencing technologies …

Motivation Transcription factor (TF) coordination plays a key role in gene regulation via
direct and/or indirect protein-protein interactions (PPIs) and DNA co-binding to regulatory …

Understanding and predicting cell-type-specific gene regulatory networks (GRNs) is
essential for unraveling the complex interactions between transcription factors (TFs) that …