Metabolomics comprises the methods and techniques that are used to measure the small
molecule composition of biofluids and tissues, and is actually one of the most rapidly …

Data pre-processing is an essential part of chemometric data analysis, which aims to
remove unwanted variation (such as instrumental artifacts) and thereby focusing on the …

Poor response to cancer therapy due to resistance remains a clinical challenge. The present
study establishes a widely prevalent mechanism of resistance to gemcitabine in pancreatic …

Metabolomics aims to provide a global snapshot of all small-molecule metabolites in cells
and biological fluids, free of observational biases inherent to more focused studies of …

Metabolic profiling, metabolomic and metabonomic studies mainly involve the
multicomponent analysis of biological fluids, tissue and cell extracts using NMR …

Metabolomics is the discipline where endogenous and exogenous metabolites are
assessed, identified and quantified in different biological samples. Metabolites are crucial …

Metabolomics is a post genomic research field concerned with developing methods for
analysis of low molecular weight compounds in biological systems, such as cells, organs or …

Background Aberrant energy metabolism is a hallmark of cancer. To fulfill the increased
energy requirements, tumor cells secrete cytokines/factors inducing muscle and fat …

Abstract 1 H NMR spectra from urine can yield information-rich data sets that offer important
insights into many biological and biochemical phenomena. However, the quality and utility …

Introduction Concerning NMR-based metabolomics, 1D spectra processing often requires
an expert eye for disentangling the intertwined peaks. Objectives The objective of …