Inflammation contributes to the pathogenesis of several diseases. Fenofibrate, known as a
peroxisome proliferator-activated receptor-α (PPAR-α) agonist, is a classic drug for treating …

Sphingolipids play an important role in the development of diabetes, both type 1 and type 2
diabetes, as well as in the development of both micro-and macro-vascular complications …

Pancreatic β-cells are prone to endoplasmic reticulum (ER) stress due to their role in insulin
secretion. They require sustainable and efficient adaptive stress responses to cope with this …

Most existing expression quantitative trait locus (eQTL) mapping studies have been focused
on individuals of European ancestry and are underrepresented in other populations …

L‐serine is classified as a non‐essential amino acid; however, L‐serine is indispensable
having a central role in a broad range of cellular processes. Growing evidence suggests a …

Aims/hypothesis Previous metabolomics studies suggest that type 1 diabetes is preceded by
specific metabolic disturbances. The aim of this study was to investigate whether distinct …

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease with insulin deficiency
due to pancreatic β cell destruction. Multiple independent cohort studies revealed specific …

Aims/hypothesis Appearance of multiple islet cell autoantibodies in early life is indicative of
future progression to overt type 1 diabetes, however, at varying rates. Here, we aimed to …

Purpose of review We provide an overview of pancreas pathology in type 1 diabetes (T1D)
in the context of its clinical stages. Recent findings Recent studies of pancreata from organ …

Background Imaging mass spectrometry enables in situ label-free detection of thousands of
metabolites from intact tissue samples. However, automated steps for multi-omics analyses …