A systematic review on the kappa opioid receptor and its ligands: New directions for the treatment of pain, anxiety, depression, and drug abuse
Kappa opioid receptor (KOR) is a member of the opioid receptor system, the G protein-
coupled receptors that are expressed throughout the peripheral and central nervous …
coupled receptors that are expressed throughout the peripheral and central nervous …
Signaling underlying kappa opioid receptor-mediated behaviors in rodents
LY Liu-Chen, P Huang - Frontiers in Neuroscience, 2022 - frontiersin.org
Kappa opioid receptor (KOR) agonists are potentially useful as analgesic and anti-pruritic
agents, for prevention and treatment of substance use disorders, and for treatment of …
agents, for prevention and treatment of substance use disorders, and for treatment of …
[HTML][HTML] Limitations and potential of κOR biased agonists for pain and itch management
The concept of ligand bias is based on the premise that different agonists can elicit distinct
responses by selectively activating the same receptor. These responses often determine …
responses by selectively activating the same receptor. These responses often determine …
Pharmacological Characterization of the Novel Selective Kappa Opioid Receptor Agonists 10-Iodo-Akuammicine and 10-Bromo-Akuammicine in Mice
K Bland, C Chen, P Huang, C Ho, T Howe… - …, 2025 - Elsevier
Akuammicine (AKC), an indole alkaloid, is a kappa opioid receptor (KOR) full agonist with a
moderate affinity. 10-Iodo-akuammicine (I-AKC) and 10-Bromo-akuammicine (Br-AKC) …
moderate affinity. 10-Iodo-akuammicine (I-AKC) and 10-Bromo-akuammicine (Br-AKC) …