Exploring orphan GPCRs in neurodegenerative diseases
Neurodegenerative disorders represent a significant and growing health burden worldwide.
Unfortunately, limited therapeutic options are currently available despite ongoing efforts …
Unfortunately, limited therapeutic options are currently available despite ongoing efforts …
Revealing the graded activation mechanism of neurotensin receptor 1
Z Wu, X Sun, J Su, X Zhang, J Hu, C Li - International Journal of Biological …, 2024 - Elsevier
Graded activation contributes to the precise regulation of GPCR activity, presenting new
opportunities for drug design. In this work, a total of 10 μs enhanced-sampling simulations …
opportunities for drug design. In this work, a total of 10 μs enhanced-sampling simulations …
High-throughput virtual screening of potential inhibitors of GPR52 using docking and biased sampling method for Huntington's disease therapy
Huntington's disease (HD) is a rare and progressive neurodegenerative disorder caused by
polyglutamine (poly-Q) mutations of the huntingtin (HTT) gene resulting in chorea, cognitive …
polyglutamine (poly-Q) mutations of the huntingtin (HTT) gene resulting in chorea, cognitive …
[HTML][HTML] 基于各项异性网络模型研究μ 阿片受体的动力学及关键位点
翟超颖 - Hans Journal of Biomedicine, 2024 - hanspub.org
阿片类药物主要通过选择性作用于μ 阿片受体(μ-opioid receptor, MOR), 激活抑制性G
蛋白来实现镇痛的效果. 由于其使用常伴随成瘾, 呼吸抑制等严重的不良反应 …
蛋白来实现镇痛的效果. 由于其使用常伴随成瘾, 呼吸抑制等严重的不良反应 …