Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …

DNA transcription and replication are two essential physiological processes that can turn
into a threat for genome integrity when they compete for the same DNA substrate. During …

ATP-dependent chromatin remodelers are commonly mutated in human cancer. Mammalian
SWI/SNF complexes comprise three conserved multisubunit chromatin remodelers (cBAF …

Uncoordinated clashes between replication forks and transcription cause replication stress
and genome instability, which are hallmarks of cancer and neurodegeneration. Here, we …

Unscheduled R loops can be a source of genome instability, a hallmark of cancer cells.
Although targeted proteomic approaches and cellular analysis of specific mutants have …

RNA: DNA hybrids form when nascent transcripts anneal to the DNA template strand or any
homologous DNA region. Co-transcriptional RNA: DNA hybrids, organized in R-loop …

Background Industrial bioethanol production may involve a low pH environment caused by
inorganic acids, improving the tolerance of Saccharomyces cerevisiae to a low pH …

Eukaryotic cells rely upon dynamic, multifaceted regulation at each step of RNA biogenesis
to maintain mRNA pools and ensure normal protein synthesis. Studies in budding yeast …

Since their discovery, R-loops have been associated with both physiological and
pathological functions that are conserved across species. R-loops are a source of replication …

Aging has become one of the fastest-growing research topics in biology. However, exactly
how the aging process occurs remains unknown. Epigenetics plays a significant role, and …