Abstract microRNAs (miRNAs) are suggested to play substantial roles in regulating the
development and various physiologic functions of the central nervous system (CNS). These …

While the root causes for individual neurodegenerative diseases are distinct, many shared
pathological features and mechanisms contribute to neurodegeneration across diseases …

The brain constantly adapts to changes in the environment, a capability that underlies
memory and behavior. Long-term adaptations require the remodeling of neural circuits that …

Astroglia play active and diverse roles in modulating neuronal/synaptic functions in the CNS.
How these astroglial functions are regulated, especially by neuronal signals, remains largely …

Brain-derived neurotrophic factor (BDNF) is an important regulator of synaptic transmission
and long-term potentiation (LTP) in the hippocampus and in other brain regions, playing a …

The size and extent of folding of the mammalian cerebral cortex are important factors that
influence a species' cognitive abilities and sensorimotor skills. Studies in various animal …

The proper formation and function of neuronal networks is required for cognition and
behavior. Indeed, pathophysiological states that disrupt neuronal networks can lead to …

An overview of miRNAs altered in Alzheimer's disease (AD) was established by profiling the
hippocampus of a cohort of 41 late‐onset AD (LOAD) patients and 23 controls, showing …

MicroRNAs (miRNAs) control gene expression by translational inhibition and destabilization
of mRNAs. While hundreds of miRNAs have been found, only a few have been studied in …

The p53 tumor suppressor protein is a critical regulator of the cellular response to cancer-
initiating insults such as genotoxic stress. In this report, we demonstrate that microRNAs …