Differences in neuroplasticity after spinal cord injury in varying animal models and humans

ME Filipp, BJ Travis, SS Henry… - Neural regeneration …, 2019 - journals.lww.com
Rats have been the primary model to study the process and underlying mechanisms of
recovery after spinal cord injury. Two weeks after a severe spinal cord contusion, rats can …

Comparative neuroanatomy of the lumbosacral spinal cord of the rat, cat, pig, monkey, and human

A Toossi, B Bergin, M Marefatallah, B Parhizi… - Scientific Reports, 2021 - nature.com
The overall goal of this work was to create a high-resolution MRI atlas of the lumbosacral
enlargement of the spinal cord of the rat (Sprague–Dawley), cat, domestic pig, rhesus …

Restoration of motor function following spinal cord injury via optimal control of intraspinal microstimulation: toward a next generation closed-loop neural prosthesis

PJ Grahn, GW Mallory, BM Berry… - Frontiers in …, 2014 - frontiersin.org
Movement is planned and coordinated by the brain and carried out by contracting muscles
acting on specific joints. Motor commands initiated in the brain travel through descending …

[HTML][HTML] Enhanced spinal cord microstimulation using conducting polymer-coated carbon microfibers

H Vara, JE Collazos-Castro - Acta biomaterialia, 2019 - Elsevier
Intraspinal microstimulation (ISMS) may help to restore motor functions after spinal cord
injury. ISMS caudal to the lesion activates motoneurons and evokes selective movements …

The role of functional neuroanatomy of the lumbar spinal cord in effect of epidural stimulation

CA Cuellar, AA Mendez, R Islam, JS Calvert… - Frontiers in …, 2017 - frontiersin.org
In this study, the neuroanatomy of the swine lumbar spinal cord, particularly the spatial
orientation of dorsal roots was correlated to the anatomical landmarks of the lumbar spine …

Spinal epidural stimulation strategies: clinical implications of locomotor studies in spinal rats

PK Shah, I Lavrov - The Neuroscientist, 2017 - journals.sagepub.com
Significant advancements in spinal epidural stimulation (ES) strategies to enable volitional
motor control in persons with a complete spinal cord injury (SCI) have generated much …

A porcine model of peripheral nerve injury enabling ultra-long regenerative distances: surgical approach, recovery kinetics, and clinical relevance

JC Burrell, KD Browne, JL Dutton, FA Laimo, S Das… - …, 2020 - journals.lww.com
BACKGROUND Millions of Americans experience residual deficits from traumatic peripheral
nerve injury (PNI). Despite advancements in surgical technique, repair typically results in …

Quantification of porcine lower thoracic spinal cord morphology with intact dura mater using high‐resolution μCT

J Chin, ML Settell, MK Brucker‐Hahn… - Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose Spinal cord stimulation (SCS) is approved by the Food
and Drug Administration for treating chronic intractable pain in the back, trunk, or limbs …

Overground gait kinematics and muscle activation patterns in the Yucatan mini pig

S Mirkiani, DA Roszko, CL O'Sullivan… - Journal of Neural …, 2022 - iopscience.iop.org
Objective. The objectives of this study were to assess gait biomechanics and the effect of
overground walking speed on gait parameters, kinematics, and electromyographic (EMG) …

A fully implantable and programmable epidural spinal cord stimulation system for rats with spinal cord injury

G Mao, Z Zhou, H Su, Y Chen, J Zhang… - … on Neural Systems …, 2023 - ieeexplore.ieee.org
Epidural spinal cord stimulation (ESCS) is a potential treatment for the recovery of the motor
function in spinal cord injury (SCI) patients. Since the mechanism of ESCS remains unclear …