Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) is a
serine/threonine kinase that belongs to the DYRK family of proteins, a subgroup of the …

Despite recent advances in our understanding of the disease, glioblastoma (GB) continues
to have limited treatment options and carries a dismal prognosis for patients. Efforts to stratify …

Abstract Three-dimensional (3D) bioprinting of living structures with cell-laden biomaterials
has been achieved in vitro, however, some cell-cell interactions are limited by the existing …

Glioblastoma (GBM) is the most common primary malignant central nervous system tumor.
The current treatment is mainly surgical resection combined with radiotherapy …

High-grade diffuse glioma (HGG) is the leading cause of brain tumour death. While the
genetic drivers of HGG have been well described, targeting these has thus far had little …

DYRK1A (dual-specificity tyrosine-regulated kinase 1A) is a kinase with multiple implications
for embryonic development, especially in the nervous system where it regulates the balance …

The Repressor Element 1 Silencing Transcription factor (REST/NRSF) is a master repressor
of neuronal programs in non-neuronal lineages shown to function as a central regulator of …

Over a century ago, the phenothiazine dye, methylene blue, was discovered to have both
antipsychotic and anti-cancer effects. In the 20th-century, the first phenothiazine …

Background The repressor element-1 silencing transcription factor (REST), a master
transcriptional repressor, is essential for maintenance, self-renewal, and differentiation in …

The timely transition from neural progenitor to post-mitotic neuron requires down-regulation
and loss of the neuronal transcriptional repressor, REST. Here, we have used mice …