Copper is too redox active to exist in an unbound form in the cell without causing oxidative
damage: an upper limit of 10-18 M for the free concentration of Cu (II) in unstressed cells has …

Copper is a trace element, important for the function of many cellular enzymes. Copper ions
can adopt distinct redox states oxidized Cu (II) or reduced (I), allowing the metal to play a …

The cause of Alzheimer's disease (AD) is closely related to the aggregation of a normal
protein, β-amyloid (Aβ), within the neocortex. Recently, evidence has been gathered to …

The basic role of metal ions including copper, zinc and iron in neurological pathologies is
generally accepted. The relationship between the development of disease and particular …

Copper is an essential trace metal which plays a fundamental role in the biochemistry of the
human nervous system. Menkes disease and Wilson disease are inherited disorders of …

The cellular uptake and intracellular distribution of the essential but highly toxic nutrient,
copper, is a precisely orchestrated process. Copper homeostasis is coordinated by several …

Data are now rapidly accumulating to show that metallochemical reactions might be the
common denominator underlying Alzheimer's disease, amyotrophic lateral sclerosis, prion …

Prion diseases result from conformational alteration of PrP C, a cell surface glycoprotein
expressed in brain, spinal cord, and several peripheral tissues, into PrP Sc, a protease …

An unidentified environmental reservoir of infectivity contributes to the natural transmission
of prion diseases (transmissible spongiform encephalopathies [TSEs]) in sheep, deer, and …

Zeolites are crystalline tectoaluminosilicates, whose structure is formed by TO4 tetrahedra
(Tà Al, Si) and each apical oxygen atom is shared between two adjacent tetrahedra. The …