The spectrin-based membrane skeleton of the humble mammalian erythrocyte has provided
biologists with a set of interacting proteins with diverse roles in organization and survival of …

Efficient and rapid propagation of action potentials in myelinated axons depends on the
molecular specialization of the nodes of Ranvier. The nodal region is organized into several …

The orientation of cell division along the long axis of the interphase cell—the century-old
Hertwig's rule—has profound roles in tissue proliferation, morphogenesis, architecture and …

▪ Abstract The polarized architecture of epithelial cells and tissues is a fundamental
determinant of animal anatomy and physiology. Recent progress made in the genetic and …

The function of a complex nervous system depends on an intricate interplay between
neuronal and glial cell types. One of the many functions of glial cells is to provide an efficient …

Systematic genetic approaches have provided deep insight into the molecular and cellular
mechanisms that operate in simple unicellular organisms. For multicellular organisms …

The entire length of myelinated axons is organized into a series of polarized domains that
center around nodes of Ranvier. These domains, which are crucial for normal saltatory …

Many organs contain epithelial tubes that transport gases or liquids [1]. Proper tube size and
shape is crucial for organ function, but the mechanisms controlling tube diameter and length …

The function of epithelial cell sheets depends on the integrity of specialized cell–cell
junctions that connect neighbouring cells. We have characterized the novel coiled-coil …

The function of tubular epithelial organs like the kidney and lung is critically dependent on
the length and diameter of their constituting branches. Genetic analysis of tube size control …