Understanding the common mechanisms of heart and skeletal muscle wasting in cancer cachexia
V Rausch, V Sala, F Penna, PE Porporato, A Ghigo - Oncogenesis, 2021 - nature.com
Cachexia is a severe complication of cancer that adversely affects the course of the disease,
with currently no effective treatments. It is characterized by a progressive atrophy of skeletal …
with currently no effective treatments. It is characterized by a progressive atrophy of skeletal …
Redox biology of regulated cell death in cancer: A focus on necroptosis and ferroptosis
Redox changes and generation of reactive oxygen species (ROS) are part of normal cell
metabolism. While low ROS levels are implicated in cellular signaling pathways necessary …
metabolism. While low ROS levels are implicated in cellular signaling pathways necessary …
GDF-15 neutralization alleviates platinum-based chemotherapy-induced emesis, anorexia, and weight loss in mice and nonhuman primates
Platinum-based cancer therapy is restricted by dose-limiting side effects and is associated
with elevation of growth differentiation factor 15 (GDF-15). But whether this elevation …
with elevation of growth differentiation factor 15 (GDF-15). But whether this elevation …
Skeletal muscle deconditioning in breast cancer patients undergoing chemotherapy: current knowledge and insights from other cancers
Breast cancer represents the most commonly diagnosed cancer while neoadjuvant and
adjuvant chemotherapies are extensively used in order to reduce tumor development and …
adjuvant chemotherapies are extensively used in order to reduce tumor development and …
Chemotherapy-induced myopathy: the dark side of the cachexia sphere
Simple Summary In addition to cancer-related factors, anti-cancer chemotherapy treatment
can drive life-threatening body wasting in a syndrome known as cachexia. Emerging …
can drive life-threatening body wasting in a syndrome known as cachexia. Emerging …
Barriers to cancer nutrition therapy: excess catabolism of muscle and adipose tissues induced by tumour products and chemotherapy
DL Schiessel, VE Baracos - Proceedings of the Nutrition Society, 2018 - cambridge.org
Cancer-associated malnutrition is driven by reduced dietary intake and by underlying
metabolic changes (such as inflammation, anabolic resistance, proteolysis, lipolysis and …
metabolic changes (such as inflammation, anabolic resistance, proteolysis, lipolysis and …
Targeting mitochondria and oxidative stress in cancer-and chemotherapy-induced muscle wasting
Significance: Cancer is frequently associated with the early appearance of cachexia, a
multifactorial wasting syndrome. If not present at diagnosis, cachexia develops either as a …
multifactorial wasting syndrome. If not present at diagnosis, cachexia develops either as a …
Impact of dose, sex, and strain on oxaliplatin-induced peripheral neuropathy in mice
UO Warncke, W Toma, JA Meade, AJ Park… - Frontiers in Pain …, 2021 - frontiersin.org
Chemotherapy-induced peripheral neuropathy (CIPN) is a common, dose limiting, and long-
lasting side effect of chemotherapy treatment. Unfortunately, no treatment has proven …
lasting side effect of chemotherapy treatment. Unfortunately, no treatment has proven …
The role of mitochondria in phytochemically mediated disease amelioration
Mitochondrial dysfunction may cause cell death, which has recently emerged as a cancer
prevention and treatment strategy mediated by chemotherapy drugs or phytochemicals …
prevention and treatment strategy mediated by chemotherapy drugs or phytochemicals …
PARP inhibition in platinum-based chemotherapy: Chemopotentiation and neuroprotection
RM McQuade, V Stojanovska, JC Bornstein… - Pharmacological …, 2018 - Elsevier
Cisplatin, carboplatin and oxaliplatin represent the backbone of platinum therapy for several
malignancies including head and neck, lung, colorectal, ovarian, breast, and genitourinary …
malignancies including head and neck, lung, colorectal, ovarian, breast, and genitourinary …