Mutations in the gene superoxide dismutase 1 (SOD1) are causative for familial forms of the
neurodegenerative disease amyotrophic lateral sclerosis. When the first SOD1 mutations …

Cu/Zn superoxide dismutase (SOD1) is a frontline antioxidant enzyme catalysing superoxide
breakdown and is important for most forms of eukaryotic life. The evolution of aerobic …

Autophagy is markedly impaired in Alzheimer's disease (AD). Here we reveal unique
autophagy dysregulation within neurons in five AD mouse models in vivo and identify its …

Context Amyloid plaques, a major pathological feature of Alzheimer disease (AD), are
composed of an internal fragment of amyloid precursor protein (APP): the 4-kd amyloid-β …

A transmembrane aspartyl protease termed β-site APP cleavage enzyme 1 (BACE1) that
cleaves the amyloid-β precursor protein (APP), which is abundant in neurons, is required for …

Summary β-site APP cleaving enzyme-1 (BACE1), the rate-limiting enzyme for β-amyloid
(Aβ) production, is elevated in Alzheimer's disease (AD). Here, we show that energy …

Animal models aim to replicate the symptoms, the lesions or the cause (s) of Alzheimer
disease. Numerous mouse transgenic lines have now succeeded in partially reproducing its …

The E693Q mutation in the amyloid beta precursor protein (APP) leads to cerebral amyloid
angiopathy (CAA), with recurrent cerebral hemorrhagic strokes and dementia. In contrast to …

β-Site amyloid precursor protein cleaving enzyme 1 (BACE1)(β-secretase) initiates
generation of β-amyloid (Aβ), which plays an early role in Alzheimer's disease (AD). BACE1 …

Amyloid-β peptide, which accumulates in senile plaques in Alzheimer's disease, is derived
from the amyloid precursor protein (APP) by proteolytic processing. β-secretase (Asp2) …