Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …

Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Histone acetylation is a ubiquitous hallmark of transcription, but whether the link between
histone acetylation and transcription is causal or consequential has not been addressed …

CpG islands (CGIs) represent a widespread feature of vertebrate genomes, being
associated with~ 70% of all gene promoters. CGIs control transcription initiation by …

The biological functions of sirtuin 6 (SIRT6; eg, deacetylation, defatty‐acylation, and mono‐
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …

Deregulation of protein post-translational modifications is intensively involved in the etiology
of diseases, including degenerative diseases, inflammatory injuries, and cancers …

As an important NAD+-dependent enzyme, SIRT6 has received significant attention since its
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …

Abstract Cyclin-dependent kinase 9 (CDK9), the kinase component of positive transcription
elongation factor b (P-TEFb), is essential for transcription of most protein-coding genes by …

Nucleosomes wrap DNA and impede access for the machinery of transcription. The core
histones that constitute nucleosomes are subject to a diversity of posttranslational …

Protein acetylation is conserved across phylogeny and has been recognized as one of the
most prominent post-translational modifications since its discovery nearly 60 years ago …