Epigallocatechin-3-gallate: A phytochemical as a promising drug candidate for the treatment of Parkinson's disease

Y Wang, S Wu, Q Li, W Lang, W Li, X Jiang… - Frontiers in …, 2022 - frontiersin.org
Epigallocatechin 3-gallate (EGCG), an abundant polyphenolic component derived from
green tea extract, possesses versatile bioactivities that can combat many diseases. During …

Microglia and astrocytes dysfunction and key neuroinflammation-based biomarkers in Parkinson's disease

K Chen, H Wang, I Ilyas, A Mahmood, L Hou - Brain Sciences, 2023 - mdpi.com
Parkinson's disease (PD) is the second most common neurodegenerative disease, with
symptoms such as tremor, bradykinesia with rigidity, and depression appearing in the late …

Lactobacillus plantarum CCFM405 against Rotenone-Induced Parkinson's Disease Mice via Regulating Gut Microbiota and Branched-Chain Amino Acids …

C Chu, L Yu, Y Li, H Guo, Q Zhai, W Chen, F Tian - Nutrients, 2023 - mdpi.com
Recent studies have demonstrated that disturbances in the gut microbiota and microbiota-
derived metabolites contribute to the pathogenesis of Parkinson's disease (PD), suggesting …

[HTML][HTML] Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence

X Liu, Y Liu, J Liu, H Zhang, C Shan… - Neural Regeneration …, 2024 - journals.lww.com
A growing body of evidence suggests that the gut microbiota contributes to the development
of neurodegenerative diseases via the microbiota-gut-brain axis. As a contributing factor …

Lewy bodies, iron, inflammation and neuromelanin: pathological aspects underlying Parkinson's disease

P Riederer, T Nagatsu, MBH Youdim, M Wulf… - Journal of Neural …, 2023 - Springer
Since the description of some peculiar symptoms by James Parkinson in 1817, attempts
have been made to define its cause or at least to enlighten the pathology of “Parkinson's …

Neuroinflammation and mitochondrial dysfunction in parkinson's disease: connecting neuroimaging with pathophysiology

BM Pizarro-Galleguillos, L Kunert, N Brüggemann… - Antioxidants, 2023 - mdpi.com
There is a pressing need for disease-modifying therapies in patients suffering from
neurodegenerative diseases, including Parkinson's disease (PD). However, these disorders …

QEEG indices are associated with inflammatory and metabolic risk factors in Parkinson's disease dementia: an observational study

H Liu, B Deng, H Zhou, Z Wu, Y Chen, G Weng… - …, 2022 - thelancet.com
Background Quantitative electroencephalography (QEEG) is a reliable and non-invasive
diagnostic tool to quantify cortical synaptic injury or loss in the clinical assessment of …

Inflammatory blood biomarkers are associated with long-term clinical disease severity in Parkinson's disease

DH Hepp, TA van Wageningen, KL Kuiper… - International journal of …, 2023 - mdpi.com
An altered immune response has been identified as a pathophysiological factor in
Parkinson's disease (PD). We aimed to identify blood immunity-associated proteins that …

New insight on microglia activation in neurodegenerative diseases and therapeutics

Y Xu, W Gao, Y Sun, M Wu - Frontiers in Neuroscience, 2023 - frontiersin.org
Microglia are immune cells within the central nervous system (CNS) closely linked to brain
health and neurodegenerative diseases such as Alzheimer's disease and Parkinson's …

The Role of IL-6 in Neurodegenerative Disorders

C Shan, C Zhang, C Zhang - Neurochemical Research, 2024 - Springer
Abstract “Neurodegenerative disorder” is an umbrella term for a group of fatal progressive
neurological illnesses characterized by neuronal loss and inflammation. Interleukin-6 (IL-6) …