The neural circuits responsible for animal behavior remain largely unknown. We summarize
new methods and present the circuitry of a large fraction of the brain of the fruit fly …

The cerebellar microcircuit has been the work bench for theoretical and computational
modeling since the beginning of neuroscientific research. The regular neural architecture of …

Computational modeling has been indispensable for understanding how subcellular
neuronal features influence circuit processing. However, the role of dendritic computations …

Dendrites integrate inputs nonlinearly, but it is unclear how these nonlinearities contribute to
the overall input-output transformation of single neurons. We developed statistically …

Bioelectronic medicine is driving the need for neuromorphic microcircuits that integrate raw
nervous stimuli and respond identically to biological neurons. However, designing such …

Cardiac rhythm management devices provide therapies for both arrhythmias and
resynchronisation but not heart failure, which affects millions of patients worldwide. This …

We report on the construction of neuron models by assimilating electrophysiological data
with large-scale constrained nonlinear optimization. The method implements interior point …

Detailed conductance-based nonlinear neuron models consisting of thousands of synapses
are key for understanding of the computational properties of single neurons and large …

Brain neurons exhibit complex electroresponsive properties–including intrinsic subthreshold
oscillations and pacemaking, resonance and phase-reset–which are thought to play a …

The neurons of the olivocerebellar circuit exhibit complex electroresponsive dynamics,
which are thought to play a fundamental role for network entraining, plasticity induction …