A comprehensive review on thiazole based conjugates as anti-cancer agents
Over the past few decades, a significant number of anticancer drugs have been developed,
both natural and synthetic. Thiazole, a 5-membered distinctive heterocyclic motif with …
both natural and synthetic. Thiazole, a 5-membered distinctive heterocyclic motif with …
Designing strategies, structural activity relationship and biological activity of recently developed nitrogen containing heterocyclic compounds as epidermal growth …
Cancer cells have the ability of dysregulation and autonomous proliferation due to
unchecked production of definite molecules. These molecules are involved in the cell growth …
unchecked production of definite molecules. These molecules are involved in the cell growth …
Indenyl-thiazole and indenyl-formazan derivatives: Synthesis, anticancer screening studies, molecular-docking, and pharmacokinetic/molin-spiration properties
GH Alfaifi, TA Farghaly, MH Abdellattif - Plos one, 2023 - journals.plos.org
Two new series of thiazole and formazan linked to 5-Bromo-indan were synthesized, and
their structures were assured based on all possible analytical techniques. The size of the …
their structures were assured based on all possible analytical techniques. The size of the …
Synthesis, anticancer evaluation, and molecular docking studies of thiazolyl-pyrazoline derivatives
The molecular hybridization of thiazole and pyrazoline heterocyclic structures with diverse
activities appears to be an interesting strategy for developing new anticancer compounds …
activities appears to be an interesting strategy for developing new anticancer compounds …
Synthesis, cytotoxic, and antioxidant activity of some benzoquinoline-based heterocycles
A series of benzoquinoline-based heterocycles was synthesized using 2-((3-chlorobenzo [f]
quinolin-2-yl) methylene) hydrazine-1-carbothioamide as a key material via condensation of …
quinolin-2-yl) methylene) hydrazine-1-carbothioamide as a key material via condensation of …
Synthesis of 3-sulfonylisoindolin-1-ones from olefinic amides and sodium sulfinates via electrooxidative tandem cyclization
X Wang, Z Zhao, J Guo, J Wang, J Zhao - Organic & Biomolecular …, 2024 - pubs.rsc.org
Sulfonyl groups are motifs that are widely found in biologically active compounds and drug
molecules, many isolated natural products as well as pharmaceuticals contain sulfonyl …
molecules, many isolated natural products as well as pharmaceuticals contain sulfonyl …
Novel 6, 7, 8-trihydrobenzo [6', 7'] cyclohepta [2', 1'-e] pyrazolo [2, 3-a] pyrimidine derivatives as Topo IIα inhibitors with potential cytotoxic activity
TA Farghaly, HG Abdulwahab, HY Medrasi… - Bioorganic …, 2022 - Elsevier
Abstract Novel tetracyclic pyrazolo [1, 5-a] pyrimidine derivatives; namely benzo [3, 4]
cyclohepta [1, 2-e] pyrazolo [1, 5-a] pyrimidin-2-amines 6a-e and benzo [3, 4] cyclohepta [1 …
cyclohepta [1, 2-e] pyrazolo [1, 5-a] pyrimidin-2-amines 6a-e and benzo [3, 4] cyclohepta [1 …
Modified pyrido [2, 3-d] pyrimidin-4 (3H)-one derivatives as EGFRWT and EGFRT790M inhibitors: Design, synthesis, and anti-cancer evaluation
ES Nossier, RA Alasfoury, M Hagras… - Journal of Molecular …, 2022 - Elsevier
This study reports design and synthesis of thirteen pyrido [2, 3-d] pyrimidin-4 (3H)-one
derivatives as EGFR inhibitors. The antiproliferation activities were tested for all compounds …
derivatives as EGFR inhibitors. The antiproliferation activities were tested for all compounds …
Design, Synthesis, antimicrobial screening and molecular modeling of novel 6, 7 dimethylquinoxalin-2 (1H)-one and thiazole derivatives targeting DNA gyrase …
RM Alqurashi, TA Farghaly, R Sabour… - Bioorganic …, 2023 - Elsevier
Abstract New 6, 7-dimethylquinoxalin-2 (1H)-one and hydrazineylidene thiazol-4-one
derivatives were synthesized, and evaluated for their in vitro antimicrobial activity. The …
derivatives were synthesized, and evaluated for their in vitro antimicrobial activity. The …
Design and synthesis of thiazole scaffold-based small molecules as anticancer agents targeting the human lactate dehydrogenase A enzyme
A new series of thiazole central scaffold-based small molecules of h LDHA inhibitors were
designed using an in silico approach. Molecular docking analysis of designed molecules …
designed using an in silico approach. Molecular docking analysis of designed molecules …