COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects

DM Smadja, SJ Mentzer, M Fontenay, MA Laffan… - Angiogenesis, 2021 - Springer
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is presenting as a systemic disease associated with …

[HTML][HTML] Derangement of the endothelial glycocalyx in sepsis

T Iba, JH Levy - Journal of Thrombosis and Haemostasis, 2019 - Elsevier
The vascular endothelial surface is coated by the glycocalyx, a ubiquitous gel‐like layer
composed of a membrane‐binding domain that contains proteoglycans, glycosaminoglycan …

[HTML][HTML] Endothelial glycocalyx

CA Foote, RN Soares, FI Ramirez-Perez… - Comprehensive …, 2022 - ncbi.nlm.nih.gov
The glycocalyx is a polysaccharide structure that protrudes from the body of a cell. It is
primarily conformed of glycoproteins and proteoglycans, which provide communication …

Role of albumin in the preservation of endothelial glycocalyx integrity and the microcirculation: a review

C Aldecoa, JV Llau, X Nuvials, A Artigas - Annals of Intensive Care, 2020 - Springer
The endothelial glycocalyx comprises a complex layer of membrane-bound proteoglycans,
secreted glycosaminoglycans, glycoproteins, glycolipids and bound plasma proteins such …

Vascular endothelial glycocalyx damage in COVID-19

M Yamaoka-Tojo - International Journal of Molecular Sciences, 2020 - mdpi.com
The new coronavirus disease-2019 (COVID-19), which is spreading around the world and
threatening people, is easily infecting a large number of people through airborne droplets; …

The glycocalyx as a permeability barrier: basic science and clinical evidence

RO Dull, RG Hahn - Critical Care, 2022 - Springer
Preclinical studies in animals and human clinical trials question whether the endothelial
glycocalyx layer is a clinically important permeability barrier. Glycocalyx breakdown …

Association of sublingual microcirculation parameters and endothelial glycocalyx dimensions in resuscitated sepsis

A Rovas, LM Seidel, H Vink, T Pohlkötter, H Pavenstädt… - Critical care, 2019 - Springer
Background The endothelial glycocalyx (eGC) covers the luminal surface of the vascular
endothelium and plays an important protective role in systemic inflammatory states and …

Human glycocalyx shedding: systematic review and critical appraisal

RG Hahn, V Patel, RO Dull - Acta Anaesthesiologica …, 2021 - Wiley Online Library
Abstracts Background The number of studies measuring breakdown products of the
glycocalyx in plasma has increased rapidly during the past decade. The purpose of the …

Shear stress regulation of endothelial glycocalyx structure is determined by glucobiosynthesis

G Wang, S Kostidis, GL Tiemeier… - … , and vascular biology, 2020 - Am Heart Assoc
Objective: Endothelial cells exposed to laminar shear stress express a thick glycocalyx on
their surface that plays an important role in reducing vascular permeability and endothelial …

The glycocalyx—linking albuminuria with renal and cardiovascular disease

TJ Rabelink, D De Zeeuw - Nature reviews nephrology, 2015 - nature.com
Albuminuria is commonly used as a marker of kidney disease progression, but some
evidence suggests that albuminuria also contributes to disease progression by inducing …