Parkinson's disease (PD) is a devastating and highly prevalent neurodegenerative disease
for which only symptomatic treatment is available. In order to develop a truly effective …

Neurodegenerative diseases are progressive degenerative conditions characterized by the
functional deterioration and ultimate loss of neurons. These incurable and debilitating …

Ferroptosis—an iron-dependent, non-apoptotic cell death process—is involved in various
degenerative diseases and represents a targetable susceptibility in certain cancers. The …

Investigation of the toxicity triggered by chemicals on the human brain has traditionally relied
on approaches using rodent in vivo models and in vitro cell models including primary …

Having appropriate in vivo and in vitro systems that provide translational models for human
disease is an integral aspect of research in neurobiology and the neurosciences. Traditional …

The use of primary mammalian neurons derived from embryonic central nervous system
tissue is limited by the fact that once terminally differentiated into mature neurons, the cells …

Genome damage and their defective repair have been etiologically linked to degenerating
neurons in many subtypes of amyotrophic lateral sclerosis (ALS) patients; however, the …

SH-SY5Y human neuroblastoma cell line:in vitrocell model of... : Chinese Medical Journal
SH-SY5Y human neuroblastoma cell line:in vitrocell model of dopaminergic neurons in …

Cholinergic transmission is critical to high-order brain functions such as memory, learning,
and attention. Alzheimer's disease (AD) is characterized by cognitive decline associated …

The identification of neurological symptoms caused by vitamin A deficiency pointed to a
critical, early developmental role of vitamin A and its metabolite, retinoic acid (RA). The …