Hypothermic machine perfusion (HMP) has become the new gold standard in clinical donor
kidney preservation and a promising novel strategy in higher risk donor livers in several …

Long-time ischemia worsening transplant outcomes in vascularized composite
allotransplantation (VCA) is often neglected. Ischemia-reperfusion injury (IRI) is an …

Over the past twenty years, significant technical strides have been made in the area of
vascularized composite tissue allotransplantation (VCA). As in solid organ transplantation …

Vascularized composite allotransplantation (VCA) represents a clinical challenge for
transplant therapy, as it involves different tissues with unique immunogenicity. Even when …

Background Limb loss has a drastic impact on a patient's life. Severe trauma to the
extremities is common in current military conflicts. Among other aspects,“life before limb” …

The current gold standard for preserving vascularized composite allografts (VCA) is 4° C
static cold storage (SCS), albeit muscle vulnerability to ischemia can be described as early …

Background. Hypothermic ex situ perfusion (HESP) systems are used to prolong allograft
survival in solid organ transplantations and have been shown to be superior to static cold …

BACKGROUND The two approaches to vascularized tissue machine perfusion use either
the open (nonpressurized) or closed (pressurized) perfusion system. Most studies …

Abstract Purpose of Review In this review, we aim to introduce the concept of machine
perfusion of vascularized composite allografts (VCAs). We briefly discuss the basic elements …

PURPOSE: The various physiological profiles comprising vascularized composite allografts
(VCAs) pose unique challenges to preservation. Minimizing ischemia, reperfusion injury …