The Notch signaling pathway plays an essential role in a wide variety of biological
processes including cell fate determination of vascular endothelial cells and the regulation …

Background Triple-negative breast cancer (TNBC) is a heterogeneous, aggressive
phenotype of breast cancer with associated chemoresistance. The development of chemo-or …

Triple‐negative breast cancer (TNBC) is a subgroup of 15%‐20% of diagnosed breast
cancer patients. It is generally considered to be the most difficult breast cancer subtype to …

Cancer constitutes a grave problem nowadays in view of the fact that it has become one of
the main causes of death worldwide. Poor clinical prognosis is presumably due to cancer …

BRCA1 mutation carriers have a higher risk of developing triple-negative breast cancer
(TNBC), which is a refractory disease due to its non-responsiveness to current clinical …

The Notch signalling pathway is a highly conserved developmental signalling pathway, with
vital roles in determining cell fate during embryonic development and tissue homeostasis …

Human papillomaviruses (HPV) are a major cause of malignancy worldwide, contributing
to~ 5% of all human cancers including almost all cases of cervical cancer and a growing …

The Notch family consists of four highly conserved transmembrane receptors. The release of
the active intracellular domain requires the enzymatic activity of γ-secretase. Notch is …

Abstract Triple Negative Breast Cancer (TNBC) is the most aggressive breast cancer
subtype suffering from limited targeted treatment options. Following recent reports …

Background Patients with triple negative breast cancer (TNBC) exhibit poor prognosis and
are at high risk of tumour relapse, due to the resistance to chemotherapy. These aggressive …