Abstract Apolipoprotein A1 (ApoA1) is a member of the Apolipoprotein family of proteins. It's
a vital protein that helps in the production of high-density lipoprotein (HDL) particles, which …

Site-directed mutagenesis and other molecular biology-based techniques are now available
for probing the amphipathic alpha helix structural motif in the exchangeable apolipoproteins …

A major interest in human genetics is to determine whether a nonsynonymous single-base
nucleotide polymorphism (nsSNP) in a gene affects its protein product and, consequently …

Apoptotic cell death following injury of vascular endothelium is assumed to play an important
role in the pathogenesis of atherosclerosis. In this report, we demonstrate that high density …

The inverse relationship between high density lipoprotein (HDL) plasma levels and coronary
heart disease has been attributed to the role that HDL and its major constituent …

Publisher Summary The dominant structural motif of the peripheral apolipoproteins is the
amphipathic helix, which is responsible for the reversible association of these proteins with …

Plasma levels of HDL cholesterol (HDL-C) predict the risk of cardiovascular disease at the
epidemiological level, but a direct causal role for HDL in cardiovascular disease remains …

A low high-density lipoprotein (HDL) plasma concentration and the abundance of small
dense low-density lipoproteins (LDL) are risk factors for developing type 2 diabetes. We …

Decreased levels of plasma high density lipoprotein (HDL) cholesterol have been
associated with premature cardiovascular disease (CVD). Tangier disease is an autosomal …

Approximately 46 human apolipoprotein AI (apoA-I) coding sequence mutations have been
reported to date. Roughly half of these mutations are associated with lower than average …