How do chemotherapeutic agents damage the ovary?

S Morgan, RA Anderson, C Gourley… - Human reproduction …, 2012 - academic.oup.com
BACKGROUND Chemotherapy treatment in premenopausal women is associated with an
increased risk of premature ovarian failure (POF) but the exact mechanism through which …

Human mesenchymal stem cell treatment of premature ovarian failure: new challenges and opportunities

YX Fu, J Ji, F Shan, J Li, R Hu - Stem Cell Research & Therapy, 2021 - Springer
Premature ovarian failure (POF) is one of the common disorders found in women leading to
1% female infertility. Clinical features of POF are hypoestrogenism or estrogen deficiency …

Safety of fertility preservation by ovarian stimulation with letrozole and gonadotropins in patients with breast cancer: a prospective controlled study

AA Azim, M Costantini-Ferrando… - Journal of Clinical …, 2008 - ascopubs.org
Purpose Because of the accompanying increase in estrogen levels, safety of performing in
vitro fertilization (IVF) in women with breast cancer is unknown. Our goal was to determine …

Strength training stops bone loss and builds muscle in postmenopausal breast cancer survivors: a randomized, controlled trial

KM Winters-Stone, J Dobek, L Nail, JA Bennett… - Breast cancer research …, 2011 - Springer
Targeted exercise training could reduce risk factors for fracture and obesity-related diseases
that increase from breast cancer treatment, but has not been sufficiently tested. We …

[HTML][HTML] Human embryonic stem cell-derived mesenchymal stem cells improved premature ovarian failure

K Bahrehbar, MR Valojerdi, F Esfandiari… - World journal of stem …, 2020 - ncbi.nlm.nih.gov
BACKGROUND Premature ovarian failure (POF) affects many adult women less than 40
years of age and leads to infertility. According to previous reports, various tissue-specific …

Bone marrow mesenchymal stem cell transplantation improves ovarian function and structure in rats with chemotherapy-induced ovarian damage

X Fu, Y He, C Xie, W Liu - Cytotherapy, 2008 - Elsevier
Background Many investigations have reported that mesenchymal stem cell (MSC)
transplantation can ameliorate the structure and function of injured tissues. The purpose of …

Gonadotropin-releasing hormone agonists for ovarian function preservation in premenopausal women undergoing chemotherapy for early-stage breast cancer: a …

RR Munhoz, AAL Pereira, AD Sasse, PM Hoff… - JAMA …, 2016 - jamanetwork.com
Importance Chemotherapy may result in a detrimental effect on ovarian function and fertility
in premenopausal women undergoing treatment for early-stage breast cancer (EBC). To …

[HTML][HTML] Hormonal therapy in breast cancer: a model disease for the personalization of cancer care

S Puhalla, S Bhattacharya, NE Davidson - Molecular oncology, 2012 - Elsevier
The treatment of breast cancer is driven by subtype classification, of which the assessment
of hormone receptor status is one of the important determinants of therapy. The use of …

Osteoporosis: a long-term and late-effect of breast cancer treatments

CL Shapiro - Cancers, 2020 - mdpi.com
Simple Summary Osteoporosis is a prevalent condition affecting 200 million individuals
world-wide. Estimates are about one in three women will experience a fragility fracture of …

[HTML][HTML] Practical clinical guidelines for assessing and managing menopausal symptoms after breast cancer

M Hickey, C Saunders, A Partridge, N Santoro, H Joffe… - Annals of oncology, 2008 - Elsevier
Background The purpose of this study was to provide practical, evidence-based guidelines
for evaluating and treating common menopausal symptoms following breast cancer …