Protein palmitoylation plays diverse roles in regulating the trafficking, stability, and activity of
cellular proteins. The advent of click chemistry has propelled the field of protein …

S-palmitoylation (S-PALM) is a lipid modification that involves the linkage of a fatty acid
chain to cysteine residues of the substrate protein. This common posttranslational …

The mechanism controlling long-chain fatty acid (LCFA) mobilization from adipose tissue is
not well understood. Here, we investigated how the LCFA transporter CD36 regulates this …

Extracellular vesicles (EVs) are membrane-enclosed particles that play an important role in
cancer progression and have emerged as a promising source of circulating biomarkers …

Palmitoyltransferase (PAT) catalyses protein S-palmitoylation which adds 16-carbon
palmitate to specific cysteines and contributes to various biological functions. We previously …

Highlights•Protein fatty-acylation regulates many fundamental biological processes in
eukaryotes.•Chemical proteomics has expanded the potential functions of protein fatty …

Prostate cancer (PC) is a leading cause of morbidity and mortality among men worldwide.
Molecular biomarkers work in conjunction with existing clinicopathologic tools to help …

Palmitoylation is an evolutionally conserved lipid modification of proteins. Dynamic and
reversible palmitoylation controls a wide range of molecular and cellular properties of …

Protein S-acylation (also called palmitoylation) is a common post-translational modification
whose deregulation plays a key role in the pathogenesis of many diseases. Acyl-biotinyl …

S-Palmitoylation is the covalent attachment of C14: 0–C22: 0 fatty acids (mainly C16: 0
palmitate) to cysteines via thioester bonds. This lipid modification is highly abundant in …