Mechanotransduction refers to the ability of cells to sense mechanical stimuli and convert
them into biochemical signals. In this context, the key players are focal adhesions (FAs) …

AL amyloidosis is characterized by widespread deposition of immunoglobulin light chains
(LCs) as amyloid fibrils. Cardiac involvement is frequent and leads to life-threatening …

The extracellular matrix (ECM) is a dynamic scaffold within organs and tissues that enables
cell morphogenesis and provides structural support. Changes in the composition and …

Background The aim of this study was to investigate the relationship between Talin-1 and
stability of carotid atherosclerosis plaque and also find out the role of miRNA, as an …

Background: Despite surgical advances, children with tetralogy of Fallot/pulmonary
atresia/major aortopulmonary collaterals (TOF/PA/MAPCAs) are subject to chronic right …

Mechanical properties are cues for many biological processes in health or disease.
Likewise, in the heart it is becoming clearer that mechanical signals are critically involved in …

BACKGROUND Cardiac physiology depends on coupling and electrical and mechanical
coordination through the intercalated disc. Focal adhesions offer mechanical support and …

The Drosophila heart provides a simple model to examine the remodelling of muscle
insertions with growth, extracellular matrix (ECM) turnover, and fibrosis. Between hatching …

Integrins are cell surface receptors expressed ubiquitously including on cardiac cells, which
are critical for maintaining homeostasis in the cardiovascular system in health and function …

The formation of a tube-like structure is a basic step in the making of functional hearts in
vertebrates and invertebrates and therefore, its understanding provides important …