Abstract The European Collaborative on Personalized Early Detection and Prevention of
Breast Cancer (ENVISION) brings together several international research consortia working …

Breast cancer is one of the most leading causes of death for women worldwide. According to
statistics published by the International Agency for Research on Cancer (IARC), the …

Simple Summary Hereditary Breast and Ovarian Cancer syndrome (HBOC) is an inherited
trait that predisposes adults to an earlier onset of cancer than the general population. HBOC …

Poly (ADP-ribose) polymerase inhibitors (PARPi) are the first clinically approved agents
designed to exploit synthetic lethality. Based on the recent approvals, PARPi became …

Abstract The Hispanic/Latino (x) population (H/L) in the United States of America is
heterogeneous and fast growing. Cancer is the number one cause of death among H/Ls …

Next generation sequencing (NGS) provides a powerful tool in the field of medical genetics,
allowing one to perform multi-gene analysis and to sequence entire exomes (WES) …

Somatic mutational profiling is increasingly being used to identify potential targets for breast
cancer. However, limited tumor-sequencing data from Hispanic/Latinas (H/L) are available …

The DNA damage response (DDR) is a complex set of downstream pathways triggered in
response to DNA damage to maintain genomic stability. Many tumours exhibit mutations …

Hereditary Breast and Ovarian Cancer (HBOC) syndrome is a condition in which the risk of
breast and ovarian cancer is higher than in the general population. The prevalent …

Breast cancer (BC) is the most common cancer and the leading cause of cancer death in
women worldwide. Since the discovery of the highly penetrant susceptibility genes BRCA1 …