[HTML][HTML] Apelinergic system structure and function
Apelin and apela (ELABELA/ELA/Toddler) are two peptide ligands for a class A G-protein-
coupled receptor named the apelin receptor (AR/APJ/APLNR). Ligand-AR interactions have …
coupled receptor named the apelin receptor (AR/APJ/APLNR). Ligand-AR interactions have …
[HTML][HTML] Metabolic relationship between diabetes and Alzheimer's disease affected by Cyclo (His-Pro) plus zinc treatment
MK Song, DS Bischoff, AM Song, K Uyemura… - BBA clinical, 2017 - Elsevier
Abstract Background Association of Alzheimer's Disease (AD) with Type 2 Diabetes (T2D)
has been well established. Cyclo (His-Pro) plus zinc (Cyclo-Z) treatment ameliorated …
has been well established. Cyclo (His-Pro) plus zinc (Cyclo-Z) treatment ameliorated …
MP4: a machine learning based classification tool for prediction and functional annotation of pathogenic proteins from metagenomic and genomic datasets
Bacteria can exceptionally evolve and develop pathogenic features making it crucial to
determine novel pathogenic proteins for specific therapeutic interventions. Therefore, we …
determine novel pathogenic proteins for specific therapeutic interventions. Therefore, we …
Novel tetrazoloquinoline–rhodanine conjugates: highly efficient synthesis and biological evaluation
In search of new active molecules against Mycobacterium tuberculosis (MTB) H37Ra and
Mycobacterium bovis BCG, a small focused library of rhodanine incorporated …
Mycobacterium bovis BCG, a small focused library of rhodanine incorporated …
Quinolidene-rhodanine conjugates: Facile synthesis and biological evaluation
DD Subhedar, MH Shaikh, BB Shingate… - European Journal of …, 2017 - Elsevier
A series of rhodanine incorporated quinoline derivatives were efficiently synthesized using
reusable DBU acetate as ionic liquid and evaluated for their in vitro antitubercular activity …
reusable DBU acetate as ionic liquid and evaluated for their in vitro antitubercular activity …
Deletion of zmp1 improves Mycobacterium bovis BCG-mediated protection in a guinea pig model of tuberculosis
Having demonstrated previously that deletion of zinc metalloprotease zmp1 in
Mycobacterium bovis BCG increased immunogenicity of BCG vaccines, we here …
Mycobacterium bovis BCG increased immunogenicity of BCG vaccines, we here …
Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside …
M Paolino, M Brindisi, A Vallone, S Butini… - …, 2018 - Wiley Online Library
The enzyme Zmp1 is a zinc‐containing peptidase that plays a critical role in the
pathogenicity of Mycobacterium tuberculosis. Herein we describe the identification of a small …
pathogenicity of Mycobacterium tuberculosis. Herein we describe the identification of a small …
Mycobacterium tuberculosis Molecular Determinants of Infection, Survival Strategies, and Vulnerable Targets
Mycobacterium tuberculosis is the causative agent of tuberculosis, an ancient disease
which, still today, represents a major threat for the world population. Despite the advances in …
which, still today, represents a major threat for the world population. Despite the advances in …
Addressing latent tuberculosis: New advances in mimicking the disease, discovering key targets, and designing hit compounds
A Campaniço, SG Harjivan, DF Warner… - International Journal of …, 2020 - mdpi.com
Despite being discovered and isolated more than one hundred years ago, tuberculosis (TB)
remains a global public health concern arch. Our inability to eradicate this bacillus is …
remains a global public health concern arch. Our inability to eradicate this bacillus is …
Metallobiology of tuberculosis
GM Rodriguez, O Neyrolles - Molecular Genetics of …, 2014 - Wiley Online Library
Iron is absolutely required for the life of most organisms, including mycobacteria. Iron is
incorporated into proteins, either as a mono‐or binuclear species or as part of heme groups …
incorporated into proteins, either as a mono‐or binuclear species or as part of heme groups …