Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …

To date treatment of trypanosomiasis urgently requires new effective and non-toxic drugs.
The article covers some of the achievements in the search for new antitrypanosomal agents; …

Cyclic nucleotide specific phosphodiesterases (PDEs) are pivotal regulators of cellular
signaling. They are also important drug targets. Besides catalytic activity and substrate …

The establishment of a Gordon Research Conference devoted to cyclic nucleotide
phosphodiesterases has had an enormous impact on the field by facilitating collaborations …

The development of drugs for neglected infectious diseases often uses parasite-specific
enzymes as targets. We here demonstrate that parasite enzymes with highly conserved …

Kinetoplastids are unicellular, eukaryotic, flagellated protozoans containing the eponymous
kinetoplast. Within this order, the family of trypanosomatids are responsible for some of the …

One of the most promising new targets for trypanocidal drugs to emerge in recent years is
the cyclic AMP (cAMP) phosphodiesterase (PDE) activity encoded by TbrPDEB1 and …

Several trypanosomatid cyclic nucleotide phosphodiesterases (PDEs) possess a unique,
parasite-specific cavity near the ligand-binding region that is referred to as the P-pocket …

Compared with the impressive progress in understanding signal transduction pathways and
mechanisms in mammalian systems, advances in protozoan signalling processes, including …

Antiparasitic chemotherapy is an important issue for drug development. Traditionally, novel
compounds with antiprotozoan activities have been identified by screening of compound …